Platelet activation and cytokine production during hypothermic cardiopulmonary bypass - A possible correlation?

P. Ferroni, G. Speziale, G. Ruvolo, A. Giovannelli, F. M. Pulcinelli, L. Lenti, P. Pignatelli, A. Criniti, E. Tonelli, B. Marino, P. P. Gazzaniga

Research output: Contribution to journalArticlepeer-review


Cardiopulmonary bypass (CPB) is associated with impaired platelet function and a systemic inflammatory response. The present study was designed to evaluate whether any correlation between platelet activation and inflammatory response during CPB exists. The results obtained from 8 patients undergoing hypothermic CPB for cardiac surgery showed the occurrence of a moderate degree of platelet activation during CPB, demonstrated by an increase of platelet CD62P expression in correlation with an increase of β-thromboglobulin levels, with a concomitant decrease of in vitro platelet response. Plasma IL-1β levels significantly increased during CPB, with a peak between 1 and 4 h after CPB. Similarly, IL-6 levels were elevated 30 min from CPB starting, peaked at 4 h, and remained elevated after 24 h. A direct correlation was found between plasma IL-1β and IL-6 levels. A significant correlation between plasma IL-1β and β-thromboglobulin levels was also found. In turn, plasma β-thromboglobulin levels correlated with CD62P expression on activated platelets. An inverse correlation was found between in vitro platelet aggregation and plasma IL-1β or IL-6 levels. From the present results it may be speculated that platelet activation during CPB may contribute, through the release of IL-1β, to activation of endothelial cells and subsequent release of other cytokines with chemotactic and pro-inflammatory properties, thus playing an important role in the inflammatory response associated with CPB.

Original languageEnglish
Pages (from-to)58-64
Number of pages7
JournalThrombosis and Haemostasis
Issue number1
Publication statusPublished - Jul 1998

ASJC Scopus subject areas

  • Hematology


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