Platelet activation by collagen is increased in retinal vein occlusion

Giuliana Leoncini, Debora Bruzzese, Maria Grazia Signorello, Ugo Armani, Antonietta Piana, Davidina Ghiglione, Paola Camicione

Research output: Contribution to journalArticlepeer-review


Retinal vein occlusion (RVO) is the most common retinal vascular disorder second to diabetic retinopathy. The main risk factors in patients with RVO are hypertension, diabetes, hyperlipidemia, increased blood viscosity and glaucoma. The pathogenesis of RVO has not yet been clarified. In these events platelets could play a very important role. In the present study the platelet response to collagen was deeply investigated. Experiments were carried out on a selected group of RVO patients, which were compared to a group of healthy subjects matched for age, sex, clinical and metabolic characteristics. In resting and activated platelets of both groups of subjects p72syk phosphorylation, phospholipase Cγ2 phosphorylation, protein kinase C activation, intracellular calcium levels and nitric oxide formation were measured. Results show that platelets of patients were more responsive to collagen or ADP than healthy subjects and that the response was significantly different (p

Original languageEnglish
Pages (from-to)218-227
Number of pages10
JournalThrombosis and Haemostasis
Issue number2
Publication statusPublished - Feb 2007


  • Collagen
  • Human platelets
  • Retinal vein occlusion

ASJC Scopus subject areas

  • Hematology

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