I recettori alfa-adrenergici piastrinici in soggetti ipertesi in trattamento con calcio-antagonisti.

Translated title of the contribution: Platelet adrenergic alpha receptors in hypertensive subjects undergoing treatment with calcium antagonists

A. Radaelli, A. Caporotondi, C. Muggia, R. Pompei, E. Marchesi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of two different calcium-channel blocking agents on platelet alpha-2 adrenoceptors were studied in 18 mild to moderate hypertensive patients. The subjects were randomly assigned in a double blind fashion to treatment with either nifedipine 10 mg t.i.d. or tiapamil 300 b.i.d. for six weeks. Platelet alpha-2 receptors were studied before and following 6 weeks of treatment using radioligand binding assay (3H Rauwolscine). Both agents induced a reduction in alpha-2 receptors, which reached statistical significance only for nifedipine. Such a reduction may contribute to the antihypertensive effect of calcium-channel blocking drugs.

Translated title of the contributionPlatelet adrenergic alpha receptors in hypertensive subjects undergoing treatment with calcium antagonists
Original languageItalian
Pages (from-to)9-13
Number of pages5
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume66
Issue number1
Publication statusPublished - Jan 1990

ASJC Scopus subject areas

  • Medicine(all)

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