Platelet aggregates in small lung vessels and death during liver transplantation

S. Gosseye, B. Weynand, L. van Obbergh, J. M. Scheiff, D. Moulin, J. de Ville de Goyet, J. B. Otte

Research output: Contribution to journalArticle

Abstract

10 children who died suddenly during liver transplantation were found at necropsy to have extensive obstruction of small lung vessels by platelet aggregates. In 7 of these patients pulmonary artery pressure changes before death were consistent with acute obstruction of the pulmonary vascular bed. Platelet aggregates were not strikingly increased in blood vessels in other tissues. No single obvious cause for these unusual histological findings could be identified, although the presence of intravascular catheters, perioperative blood and platelet concentrate transfusions, and cellular debris from the liver forced into the circulation during surgery might predispose to platelet aggregation.

Original languageEnglish
Pages (from-to)532-534
Number of pages3
JournalLancet
Volume338
Issue number8766
DOIs
Publication statusPublished - Aug 31 1991

ASJC Scopus subject areas

  • Medicine(all)

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    Gosseye, S., Weynand, B., van Obbergh, L., Scheiff, J. M., Moulin, D., de Ville de Goyet, J., & Otte, J. B. (1991). Platelet aggregates in small lung vessels and death during liver transplantation. Lancet, 338(8766), 532-534. https://doi.org/10.1016/0140-6736(91)91099-G