Platelet aggregation and antithrombin III levels in diabetic children

E. Corbella, G. Miragliotta, R. Masperi, S. Villa, A. Bini, G. De Gaetano, G. Chiumello

Research output: Contribution to journalArticle

Abstract

We studied platelet function and antithrombrin III levels in 30 insulin-dependent diabetic children with no clinically evident vascular complications. 9 were in-patients and 21 were out-patients. The disease had been discovered within the previous 10 years. 25 control subjects of comparable age and body weight were studied simultaneously. Template bleeding time, threshold concentrations of ADP or adrenaline required to induce irreversible platelet aggregation and plasma antiheparin activity (platelet factor 4) did not differ significantly in control and patient groups. In contrast, the immunological levels of plasma antithrombin III were significantly higher in the diabetic group. These results suggest that diabetic children, with no clinical signs of microangiopathy, show no laboratory changes suggesting increased platelet function. The unexpected increase in the antithrombin III level could reflect a very early defense mechanism against activation of the blood clotting system.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalPathophysiology of Haemostasis and Thrombosis
Volume8
Issue number1
DOIs
Publication statusPublished - 1979

Fingerprint

Antithrombin III
Platelet Aggregation
Blood Platelets
Platelet Factor 4
Bleeding Time
Blood Coagulation
Adenosine Diphosphate
Epinephrine
Blood Vessels
Outpatients
Body Weight
Insulin
Control Groups

Keywords

  • Antithrombin III
  • Children
  • Diabetes
  • Platelet aggregation

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

Cite this

Platelet aggregation and antithrombin III levels in diabetic children. / Corbella, E.; Miragliotta, G.; Masperi, R.; Villa, S.; Bini, A.; De Gaetano, G.; Chiumello, G.

In: Pathophysiology of Haemostasis and Thrombosis, Vol. 8, No. 1, 1979, p. 30-37.

Research output: Contribution to journalArticle

Corbella, E, Miragliotta, G, Masperi, R, Villa, S, Bini, A, De Gaetano, G & Chiumello, G 1979, 'Platelet aggregation and antithrombin III levels in diabetic children', Pathophysiology of Haemostasis and Thrombosis, vol. 8, no. 1, pp. 30-37. https://doi.org/10.1159/000214288
Corbella, E. ; Miragliotta, G. ; Masperi, R. ; Villa, S. ; Bini, A. ; De Gaetano, G. ; Chiumello, G. / Platelet aggregation and antithrombin III levels in diabetic children. In: Pathophysiology of Haemostasis and Thrombosis. 1979 ; Vol. 8, No. 1. pp. 30-37.
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