TY - JOUR
T1 - Platelet aggregation and haemolysis induced in rats by intravenous infusion of ADP. Effect of potentially antithrombotic drugs
AU - Reyers Degli Innocenti, I.
AU - Poggi, A.
AU - De Gaetano, G.
PY - 1974
Y1 - 1974
N2 - This paper describes a simple experimental model to quantitate the in vivo aggregation of rat platelets induced by ADP and the in vivo effectiveness of compounds with potential anti aggregating activity; only drugs known to inhibit in vitro the first phases of platelet aggregation (PGE1, pyrimido pyrimidine compounds) were inhibitory in this model; in contrast, acetylsalicylic acid, known to inhibit in vitro the last phases of platelet aggregation, was ineffective; no interaction between pyrimido pyrimidine compounds and acetylsalicylic acid was observed. Besides platelet aggregation, ADP also induced a marked hemolysis; the latter was not inhibited by any of the drugs tested.
AB - This paper describes a simple experimental model to quantitate the in vivo aggregation of rat platelets induced by ADP and the in vivo effectiveness of compounds with potential anti aggregating activity; only drugs known to inhibit in vitro the first phases of platelet aggregation (PGE1, pyrimido pyrimidine compounds) were inhibitory in this model; in contrast, acetylsalicylic acid, known to inhibit in vitro the last phases of platelet aggregation, was ineffective; no interaction between pyrimido pyrimidine compounds and acetylsalicylic acid was observed. Besides platelet aggregation, ADP also induced a marked hemolysis; the latter was not inhibited by any of the drugs tested.
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M3 - Article
C2 - 4616330
AN - SCOPUS:0016333961
VL - 13
SP - 331
EP - 337
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 5
ER -