Platelet aggregation and malondialdehyde formation in type IIA hypercholesterolemic patients

Elena Tremoli, Paola Maderna, Marina Sirtori, Cesare R. Sirtori

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet aggregation induced by threshold concentrations of ADP, adrenaline, collagen and Thrombofax® was evaluated in 25 type IIA hypercholesterolemic patients in comparison with 15 control subjects. Malondialdehyde (MDA) formation induced by collagen and thrombin was also studied in a subgroup of 8 patients. In the patient group, irreversible platelet aggregation was induced by significantly lower concentrations of both adrenaline (p

Original languageEnglish
Pages (from-to)47-53
Number of pages7
JournalPathophysiology of Haemostasis and Thrombosis
Volume8
Issue number1
DOIs
Publication statusPublished - 1979

Keywords

  • Aggregation
  • Hyperaggregability
  • Hyperlipoproteinemia type IIA
  • Malondialdehyde
  • Platelets

ASJC Scopus subject areas

  • Hematology
  • Physiology (medical)

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