Platelet aggregation in platelet rich plasma and whole blood in 18 patients affected by idiopathic myelofibrosis

C. L. Balduini, G. Bertolino, G. Gamba, G. Barosi, F. Sinigaglia, P. Noris, A. Bisio, E. Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet aggregation in whole blood (WB) and in platelet rich plasma (PRP) was studied in 18 consecutive patients affected by idiopathic myelofibrosis (IM). On the basis of WB studies, 22% of patients were classified as normo-aggregating and 22% as hypo-aggregating, while 55% had spontaneous platelet aggregation (SPA). SPA was observed also when platelets from patients were stirred in the presence of normal erythrocytes, while it never occurred when normal platelets were stirred in the presence of red cells from patients. PRP studies revealed that 33% and 66% of patients were, respectively, hypo- and normo-aggregating. The most frequent abnormality in PRP was represented by defective or absent aggregation response to epinephrine.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalEuropean Journal of Haematology
Volume41
Issue number3
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Hematology

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