Platelet aggregation in platelet-rich plasma and whole blood in 120 patients with myeloproliferative disorders

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Abstract

In vitro platelet aggregation in platelet-rich plasma (PRP) and in whole blood (WB) was assessed in 31 patients with idiopathic myelofibrosis, 32 with essential thrombocytosis, 23 with polycythemia vera, and 34 with chronic myelogenous leukemia. In PRP most subjects showed normal or reduced platelet aggregation, whereas in WB the majority of patients showed increased platelet function. Spontaneous platelet aggregation (SPA) was observed frequently in WB, whereas it was seldom observed in PRP. SPA in WB was inhibited by in vitro addition of aspirin and apyrase, and SPA was only partially dependent on high platelet count because it also occurred in samples with normal platelet content (at variance with 13 subjects with reactive thrombocytosis, in which SPA was observed only in samples with high platelet concentration). Platelets from patients with idiopathic myelofibrosis had the highest tendency to undergo SPA.

Original languageEnglish
Pages (from-to)82-86
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume95
Issue number1
Publication statusPublished - 1991

Keywords

  • chronic myelogenous leukemia
  • essential thrombocytosis
  • idiopathic myelofibrosis
  • myeloproliferative disorders
  • platelet aggregation
  • polycythemia vera

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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