Abstract
To evaluate the role of serotonin in liver cirrhosis, serotonin was determined by high-performance liquid chromatography in plasma, platelets and ascitic fluids from 14 cirrhotic patients. Plasma-free serotonin was within the normal range, but intraplatelet serotonin was significantly low in cirrhosis (p = 0.001) and this decrease paralleled the severity of the disease. The concentration of serotonin in ascitic fluids was 12% of the corresponding plasma concentrations. Our data indicate that serotonin levels are influenced by hepatic injury, but the reasons for these changes are still unclear.
| Original language | English |
|---|---|
| Pages (from-to) | 419-422 |
| Number of pages | 4 |
| Journal | Clinical Chemistry and Laboratory Medicine |
| Volume | 27 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1989 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical
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Cite this
Marasini, B., Biondi, M. L., & Agostoni, A. (1989). Platelet and Plasma Serotonin in Patients with Liver Cirrhosis. Clinical Chemistry and Laboratory Medicine, 27(7), 419-422. https://doi.org/10.1515/cclm.1989.27.7.419