Platelet and Plasma Serotonin in Patients with Liver Cirrhosis

Bianca Marasini, Maria Luisa Biondi, A. Agostoni

Research output: Contribution to journalArticlepeer-review


To evaluate the role of serotonin in liver cirrhosis, serotonin was determined by high-performance liquid chromatography in plasma, platelets and ascitic fluids from 14 cirrhotic patients. Plasma-free serotonin was within the normal range, but intraplatelet serotonin was significantly low in cirrhosis (p = 0.001) and this decrease paralleled the severity of the disease. The concentration of serotonin in ascitic fluids was 12% of the corresponding plasma concentrations. Our data indicate that serotonin levels are influenced by hepatic injury, but the reasons for these changes are still unclear.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalClinical Chemistry and Laboratory Medicine
Issue number7
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical


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