The bleeding tendency of uremic patients is the consequence of abnormal platelet function which may be the result of an interaction of different factors. Dialysable factors may play some role in the hemostatic defect of uremia since they reduce platelet response to aggregating agents in vitro. Identified factors include altered arachidonic acid metabolism leading to abnormal vascular and platelet prostaglandin. Uremic plasma stimulates excessive generation of vascular prostacyclin and inhibits platelet prostaglandin formation. Unfortunately, conventional hemodialysis only partially corrects the abnormal hemostasis.
|Number of pages||8|
|Journal||Mineral and Electrolyte Metabolism|
|Publication status||Published - 1981|
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism