Platelet cytosolic calcium concentration in patients with fiver cirrhosis. Relationship with hepatic and systemic hemodynamics

Juan Carlos Bandi, Esteban Poch, Juan Carlos García-Pagán, Angelo Luca, Wladimiro Jiménez, Angels Escorsell, Juan Rodés

Research output: Contribution to journalArticle

Abstract

Background/Aims: Due to structural and functional similarities between platelets and vascular smooth muscle cells, platelet cytosolic calcium concentration ([Ca 2+](i)) has been suggested to be a useful tool to study regulatory mechanisms of peripheral vascular tone. The aim of the present study was to investigate platelet [Ca 2+](i) in patients with cirrhosis and whether this parameter is related with the systemic and splanchnic vasodilatation found in these patients. Methods: Seventeen patients with cirrhosis and eight age- and sex-matched controls were studied. Mean arterial pressure, cardiac output, femoral blood flow and basal and thrombin- stimulated platelet [Ca 2+](i) were measured. Cardiac output (thermal dilution), azygos blood flow, hepatic venous pressure gradient and hepatic blood flow were also measured in patients with cirrhosis. Results: Patients with cirrhosis had severe portal hypertension and a significantly higher cardiac output and femoral blood flow and a significantly lower systemic and femoral vascular resistance than controls. Patients with cirrhosis had a lower basal platelet [Ca 2+](i) than normal subjects. However, there was no relationship between platelet [Ca 2+](i) and any of the hemodynamic parameters that evaluate systemic or splanchnic vasodilatation. Conclusions: This study shows that cirrhotic patients with portal hypertension have a significant reduction in platelet basal [Ca 2+](i). The lack of correlation between platelet [Ca 2+](i) and hepatic and systemic hemodynamics does not support the use of platelet [Ca 2+](i) as a model to study mechanisms involved in the pathophysiology of the hyperdynamic circulation associated to portal hypertension.

Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalJournal of Hepatology
Volume27
Issue number5
DOIs
Publication statusPublished - Nov 1997

Fingerprint

Fibrosis
Blood Platelets
Hemodynamics
Calcium
Liver
Portal Hypertension
Thigh
Viscera
Vasodilation
Cardiac Output
High Cardiac Output
Venous Pressure
Vascular Smooth Muscle
Thrombin
Vascular Resistance
Smooth Muscle Myocytes
Blood Vessels
Arterial Pressure
Hot Temperature

Keywords

  • Calcium
  • Hyperdynamic circulation
  • Platelets
  • Portal hypertension

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Platelet cytosolic calcium concentration in patients with fiver cirrhosis. Relationship with hepatic and systemic hemodynamics. / Bandi, Juan Carlos; Poch, Esteban; García-Pagán, Juan Carlos; Luca, Angelo; Jiménez, Wladimiro; Escorsell, Angels; Rodés, Juan.

In: Journal of Hepatology, Vol. 27, No. 5, 11.1997, p. 824-829.

Research output: Contribution to journalArticle

Bandi, Juan Carlos ; Poch, Esteban ; García-Pagán, Juan Carlos ; Luca, Angelo ; Jiménez, Wladimiro ; Escorsell, Angels ; Rodés, Juan. / Platelet cytosolic calcium concentration in patients with fiver cirrhosis. Relationship with hepatic and systemic hemodynamics. In: Journal of Hepatology. 1997 ; Vol. 27, No. 5. pp. 824-829.
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