TY - JOUR
T1 - Platelet cytosolic calcium concentration in patients with fiver cirrhosis. Relationship with hepatic and systemic hemodynamics
AU - Bandi, Juan Carlos
AU - Poch, Esteban
AU - García-Pagán, Juan Carlos
AU - Luca, Angelo
AU - Jiménez, Wladimiro
AU - Escorsell, Angels
AU - Rodés, Juan
PY - 1997/11
Y1 - 1997/11
N2 - Background/Aims: Due to structural and functional similarities between platelets and vascular smooth muscle cells, platelet cytosolic calcium concentration ([Ca
2+](i)) has been suggested to be a useful tool to study regulatory mechanisms of peripheral vascular tone. The aim of the present study was to investigate platelet [Ca
2+](i) in patients with cirrhosis and whether this parameter is related with the systemic and splanchnic vasodilatation found in these patients. Methods: Seventeen patients with cirrhosis and eight age- and sex-matched controls were studied. Mean arterial pressure, cardiac output, femoral blood flow and basal and thrombin- stimulated platelet [Ca
2+](i) were measured. Cardiac output (thermal dilution), azygos blood flow, hepatic venous pressure gradient and hepatic blood flow were also measured in patients with cirrhosis. Results: Patients with cirrhosis had severe portal hypertension and a significantly higher cardiac output and femoral blood flow and a significantly lower systemic and femoral vascular resistance than controls. Patients with cirrhosis had a lower basal platelet [Ca
2+](i) than normal subjects. However, there was no relationship between platelet [Ca
2+](i) and any of the hemodynamic parameters that evaluate systemic or splanchnic vasodilatation. Conclusions: This study shows that cirrhotic patients with portal hypertension have a significant reduction in platelet basal [Ca
2+](i). The lack of correlation between platelet [Ca
2+](i) and hepatic and systemic hemodynamics does not support the use of platelet [Ca
2+](i) as a model to study mechanisms involved in the pathophysiology of the hyperdynamic circulation associated to portal hypertension.
AB - Background/Aims: Due to structural and functional similarities between platelets and vascular smooth muscle cells, platelet cytosolic calcium concentration ([Ca
2+](i)) has been suggested to be a useful tool to study regulatory mechanisms of peripheral vascular tone. The aim of the present study was to investigate platelet [Ca
2+](i) in patients with cirrhosis and whether this parameter is related with the systemic and splanchnic vasodilatation found in these patients. Methods: Seventeen patients with cirrhosis and eight age- and sex-matched controls were studied. Mean arterial pressure, cardiac output, femoral blood flow and basal and thrombin- stimulated platelet [Ca
2+](i) were measured. Cardiac output (thermal dilution), azygos blood flow, hepatic venous pressure gradient and hepatic blood flow were also measured in patients with cirrhosis. Results: Patients with cirrhosis had severe portal hypertension and a significantly higher cardiac output and femoral blood flow and a significantly lower systemic and femoral vascular resistance than controls. Patients with cirrhosis had a lower basal platelet [Ca
2+](i) than normal subjects. However, there was no relationship between platelet [Ca
2+](i) and any of the hemodynamic parameters that evaluate systemic or splanchnic vasodilatation. Conclusions: This study shows that cirrhotic patients with portal hypertension have a significant reduction in platelet basal [Ca
2+](i). The lack of correlation between platelet [Ca
2+](i) and hepatic and systemic hemodynamics does not support the use of platelet [Ca
2+](i) as a model to study mechanisms involved in the pathophysiology of the hyperdynamic circulation associated to portal hypertension.
KW - Calcium
KW - Hyperdynamic circulation
KW - Platelets
KW - Portal hypertension
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U2 - 10.1016/S0168-8278(97)80319-4
DO - 10.1016/S0168-8278(97)80319-4
M3 - Article
C2 - 9382969
AN - SCOPUS:0030708853
VL - 27
SP - 824
EP - 829
JO - Journal of Hepatology
JF - Journal of Hepatology
SN - 0168-8278
IS - 5
ER -