Platelet-derived growth factor and platelet-derived growth factor receptor-α expression in the normal human thymus and thymoma

Anca Maria Cimpean, Raluca Ceauşu, Svetlana Encicǎ, Pusa Nela Gaje, Domenico Ribatti, Marius Raica

Research output: Contribution to journalArticle

Abstract

Platelet-derived growth factor (PDGF) and its receptors (PDGFRs) are strongly involved in the normal development of several organs, tumour angiogenesis and malignant progression and metastasis. Few studies concerning their expression, distribution and role in normal and pathological human thymus are available in the literature. The aim of this study has been to analyse the immunohistochemical expression of PDGF and PDGFR-α in prenatal and postnatal normal human thymus and thymomal biopsy specimens. The results demonstrated immunoreactivity to both PDGF and PDGFR-α in all specimens, but the intensity, distribution and number of positive cells were different in normal thymus and thymomas, and also among different tumour types. PDGF and PDGFR-α were weakly expressed in foetal and postnatal humans with a different distribution between cortex and medulla in both blood vessels and epithelial cells, whereas they were overexpressed in thymoma, especially in type B2 and B3, in the tumour epithelial cells. Overall, these data suggest that PDGF and PDGFR-α may be involved in the pathophysiology of the human thymus.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalInternational Journal of Experimental Pathology
Volume92
Issue number5
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Platelet-Derived Growth Factor Receptors
Thymoma
Platelet-Derived Growth Factor
Thymus Gland
Epithelial Cells
Neoplasms
Blood Vessels
Blood Cells
Cell Count
Neoplasm Metastasis
Biopsy

Keywords

  • Platelet-derived growth factor
  • Platelet-derived growth factor receptor-α
  • Thymoma
  • Thymus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Molecular Biology

Cite this

Platelet-derived growth factor and platelet-derived growth factor receptor-α expression in the normal human thymus and thymoma. / Cimpean, Anca Maria; Ceauşu, Raluca; Encicǎ, Svetlana; Gaje, Pusa Nela; Ribatti, Domenico; Raica, Marius.

In: International Journal of Experimental Pathology, Vol. 92, No. 5, 10.2011, p. 340-344.

Research output: Contribution to journalArticle

Cimpean, Anca Maria ; Ceauşu, Raluca ; Encicǎ, Svetlana ; Gaje, Pusa Nela ; Ribatti, Domenico ; Raica, Marius. / Platelet-derived growth factor and platelet-derived growth factor receptor-α expression in the normal human thymus and thymoma. In: International Journal of Experimental Pathology. 2011 ; Vol. 92, No. 5. pp. 340-344.
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