Platelet derived growth factor induces ornithine decarboxylase activity in nih 3T3 cells

Elisa Vicenzi, Marina Bianchi, Mario Salmona, Maria Benedetta Donati, Andreina Poggi, Pietro Ghezzi

Research output: Contribution to journalArticlepeer-review

Abstract

Incubation with highly purified humah Platelet Derived Growth Factor induced ornithine decarboxylase activity in quiescent NIH 3T3 cells concomitantly with mitogenic stimulation. Pretreatment of cells with a specific ornithine decarboxylase inhibitor, DL-α-difluoromethyl-ornithine significantly inhibited the effect of the mitogen on DNA synthesis. These experiments suggest that the mitogenic activity of Platelet Derived Growth Factor, similarly to that of other serum growth factors or tumor promoters, is mediated through rise in polyamine levels.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume127
Issue number3
DOIs
Publication statusPublished - Mar 29 1985

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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