Platelet dysfunction in acute megakaryoblastic leukemia

Enrico M. Pogliani, Mariangela Colombi, Elisabetta Cofrancesco, Marco Salvatore, Camilla Fowst

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Platelet function profiles were studied in 3 patients with megakaryoblastic leukemia. All patients had a moderate decrease in platelet counts with abnormal platelet retention. One patient who developed hemorrhagic diathesis had prolonged bleeding time. In all patients platelet aggregation was defective after the addition of ADP, collagen, adrenaline, or U46619, a thromboxane A2 agonist. Malondialdehyde was reduced in all patients, as was platelet serotonin. Plasma β-thromboglobulin levels were normal in all cases whereas PF4 was markedly elevated in one. Platelet dysfunction was not reversed by clinical remission. These studies confirm that megakaryoblastic leukemia is associated with a thrombocytopathy which may play a role in hemorrhagic diathesis and should be taken into account in the management of these patients.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalActa Haematologica
Volume81
Issue number1
DOIs
Publication statusPublished - 1989

Fingerprint

Leukemia, Megakaryoblastic, Acute
Blood Platelets
Hemorrhagic Disorders
Leukemia
Blood Platelet Disorders
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Thromboxane A2
Bleeding Time
Malondialdehyde
Platelet Count
Platelet Aggregation
Adenosine Diphosphate
Epinephrine
Serotonin
Collagen

Keywords

  • Megakaryoblastic leukemia
  • Prostaglandin pathway
  • Release reaction
  • Thrombocytopathy

ASJC Scopus subject areas

  • Hematology

Cite this

Pogliani, E. M., Colombi, M., Cofrancesco, E., Salvatore, M., & Fowst, C. (1989). Platelet dysfunction in acute megakaryoblastic leukemia. Acta Haematologica, 81(1), 1-4. https://doi.org/10.1159/000205389

Platelet dysfunction in acute megakaryoblastic leukemia. / Pogliani, Enrico M.; Colombi, Mariangela; Cofrancesco, Elisabetta; Salvatore, Marco; Fowst, Camilla.

In: Acta Haematologica, Vol. 81, No. 1, 1989, p. 1-4.

Research output: Contribution to journalArticle

Pogliani, EM, Colombi, M, Cofrancesco, E, Salvatore, M & Fowst, C 1989, 'Platelet dysfunction in acute megakaryoblastic leukemia', Acta Haematologica, vol. 81, no. 1, pp. 1-4. https://doi.org/10.1159/000205389
Pogliani, Enrico M. ; Colombi, Mariangela ; Cofrancesco, Elisabetta ; Salvatore, Marco ; Fowst, Camilla. / Platelet dysfunction in acute megakaryoblastic leukemia. In: Acta Haematologica. 1989 ; Vol. 81, No. 1. pp. 1-4.
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