Platelet dysfunction in renal failure

Research output: Contribution to journalArticle

Abstract

Patients with end-stage renal disease suffer from complex hemostatic disorders. Uremic patients show a bleeding diathesis that is mainly due to abnormalities of primary hemostasis; in particular, platelet dysfunction and impaired platelet-vessel wall interaction. However, despite decreased platelet function, these patients have a high prevalence of cardiovascular and thrombotic complications. Platelet dysfunction in uremic patients is partially due to uremic toxins present in circulating blood. Dialysis improves platelet abnormalities and reduces, but does not eliminate, the risk of hemorrhage. Hemodialysis can even contribute to the bleeding through the continuous platelet activation induced by the interaction between blood and artificial surfaces. Thrombocytopenia, glomerular thrombosis, and thrombi in small arteries and glomerular capillaries are common pathological features in many renal diseases. Platelets are also involved directly in the pathogenesis of glomerular diseases through a variety of mechanisms, including release of active molecules, by enhancing immune complex deposition, and by altering glomerular permeability.

Original languageEnglish
Pages (from-to)579-589
Number of pages11
JournalSeminars in Thrombosis and Hemostasis
Volume30
Issue number5
DOIs
Publication statusPublished - Oct 2004

Keywords

  • Bleeding
  • Platelet
  • Renal diseases
  • Thrombosis
  • Uremia

ASJC Scopus subject areas

  • Hematology

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