Platelet function in patients on maintenance hemodialysis: Depressed or enhanced?

G. Remuzzi, A. Benigni, P. Dodesini, A. Schieppati, E. Gotti, M. Livio, G. Mecca, B. Donati, G. de Gaetano

Research output: Contribution to journalArticle

Abstract

Uremic patients on long-term hemodialysis show a paradoxical association of hemorrhages on the one hand and thrombotic complications or atherosclerosis on the other. Platelet function has been found to be depressed in some cases but enhanced in others. In 19 patients, both platelet aggregation and prostaglandin formation appeared to be significantly enhanced in response to low concentrations of arachidonic acid but significantly reduced with high concentrations. It is suggested that this double functional abnormality of uremic platelets may contribute to the complex vascular disturbances of hemodialyzed patients.

Original languageEnglish
Pages (from-to)60-63
Number of pages4
JournalClinical Nephrology
Volume17
Issue number2
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Nephrology

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