TY - JOUR
T1 - Platelet function in rheumatoid arthritis
AU - Colli, S.
AU - Maderna, P.
AU - Tremoli, E.
AU - Colombo, F.
AU - Canesi, B.
PY - 1982
Y1 - 1982
N2 - Platelet function tests were evaluated in 20 patients with rheumatoid arthritis (RA), 9 of whom displayed thrombocytosis (>400 000 platelets/μl). Most patients had an enhanced sensitivity to collagen and epinephrine induced aggregation, as compared with a reference group. In contrast, malondialdehyde (MDA) production, an index of platelet arachidonic acid metabolism, was in the normal range for all the patients except 3, who were LE phenomenon positive. The hypersensitivity of platelets to aggregating stimuli was particularly marked in thrombocytotic patients, who also showed the most striking biochemical and clinical abnormality. These findings indicate the crucial role of platelets in the development and self-sustaining of RA.
AB - Platelet function tests were evaluated in 20 patients with rheumatoid arthritis (RA), 9 of whom displayed thrombocytosis (>400 000 platelets/μl). Most patients had an enhanced sensitivity to collagen and epinephrine induced aggregation, as compared with a reference group. In contrast, malondialdehyde (MDA) production, an index of platelet arachidonic acid metabolism, was in the normal range for all the patients except 3, who were LE phenomenon positive. The hypersensitivity of platelets to aggregating stimuli was particularly marked in thrombocytotic patients, who also showed the most striking biochemical and clinical abnormality. These findings indicate the crucial role of platelets in the development and self-sustaining of RA.
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U2 - 10.3109/03009748209098179
DO - 10.3109/03009748209098179
M3 - Article
C2 - 7123174
AN - SCOPUS:0019969475
VL - 11
SP - 139
EP - 143
JO - Acta rheumatologica Scandinavica
JF - Acta rheumatologica Scandinavica
SN - 0300-9742
IS - 3
ER -