Platelet function in rheumatoid arthritis

S. Colli, P. Maderna, E. Tremoli, F. Colombo, B. Canesi

Research output: Contribution to journalArticle

Abstract

Platelet function tests were evaluated in 20 patients with rheumatoid arthritis (RA), 9 of whom displayed thrombocytosis (>400 000 platelets/μl). Most patients had an enhanced sensitivity to collagen and epinephrine induced aggregation, as compared with a reference group. In contrast, malondialdehyde (MDA) production, an index of platelet arachidonic acid metabolism, was in the normal range for all the patients except 3, who were LE phenomenon positive. The hypersensitivity of platelets to aggregating stimuli was particularly marked in thrombocytotic patients, who also showed the most striking biochemical and clinical abnormality. These findings indicate the crucial role of platelets in the development and self-sustaining of RA.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalScandinavian Journal of Rheumatology
Volume11
Issue number3
DOIs
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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