Platelet gel from cord blood: A novel tool for tissue engineering

Valentina Parazzi, Lorenza Lazzari, Paolo Rebulla

Research output: Contribution to journalArticle

Abstract

Recent findings show that growth factors (GF) play a relevant role in regenerative medicine. Platelets (PLT) may be used as "drug-stores" of GF that can be released upon activation by PLT granules. In this context, PLT gel (PG) from peripheral blood is currently used to improve tissue healing in orthopedic, oral maxillofacial and dermatologic surgery. Recent findings on multiple biological properties of human umbilical cord blood (CB) and its high level of viral safety prompted us to investigate the characteristics of its PLTs and the possibility to produce PLT gel from cord blood. Our study shows that CB PG releases high levels of vascular endothelial growth factor (VEGF) and platelet-derived growth factor-BB (PDGF-BB), substantial amounts of fibroblast growth factor (FGF), hepatocyte growth factor (HGF) and transforming growth factor-beta 1 (TGFbeta1), and minimal amounts of PDGF-AB. These findings suggest that CB PG can be a preferable tool for tissue engineering applications where high levels of VEGF and PDGF may be desirable.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalPlatelets
Volume21
Issue number7
DOIs
Publication statusPublished - Nov 2010

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Keywords

  • cord blood
  • growth factors
  • peripheral blood
  • Platelet gel

ASJC Scopus subject areas

  • Hematology

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