Platelet glutamate uptake as peripheral marker of excrtotoxicity in neurodegenerative disorders

C. Ferrarese, C. Zoia, B. Begni, G. Sala, C. Canevari, L. Frattola

Research output: Contribution to journalArticlepeer-review

Abstract

Excitotoxicity. linked to impaired glutamate uptake, is a common pathway in various neurodegenerative disorders. We investigated the expression of glutamate transporters and glutamate uptake in platelets, as peripheral markers of excitotoxieity in vivo. 34 Parkinson's disease (PD). 32 AlJ.heimer's disease (AD), 41 amyotrophic lateral selerosis (ALS) patients and age-matched healthy controls were selected. Polyclonal antipeptide antibodies for glutamate transporters (Prof. Rothstein. Baltimore, MD) were used to assess, by western blot and electron microscopy, the type of transporter present in platelets. Uptake experiments were performed using ['Hjglutamate. Both western blot and the immunogold studies revealed that the three transporters are present in human platelets. 507

Original languageEnglish
Pages (from-to)278
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume20
Issue number4
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Fingerprint

Dive into the research topics of 'Platelet glutamate uptake as peripheral marker of excrtotoxicity in neurodegenerative disorders'. Together they form a unique fingerprint.

Cite this