Platelet glycoprotein receptor IIIa polymorphism PlA1/PlA2 and coronary risk: A meta-analysis

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Abstract

Membrane glycoprotein IIb/IIIa plays a major role in platelet function. The gene encoding the glycoprotein IIIa shows a common polymorphism PlA1/PlA2 that was variably associated with vascular disease. To clarify the role of PlA1/PlA2 polymorphism in coronary risk, a meta-analysis of published data was conducted. Studies were identified both by MEDLINE searches, and hand searching of journals and abstract books. A total of 34 studies for coronary artery disease (CAD), and 6 for restenosis after revascularization were identified, for a total of 9,095 cases and 12,508 controls. In CAD, the overall odds ratio for carriers of the PlA2 allele was 1.10 (95% CI: 1.03 to 1.18), and it was 1.21 (95% CI: 1.05 to 1.38) in subjects younger than 60. Overall odds ratio was 1.31 (95% CI: 1.10 to 1.56) after revascularization procedures. The association of PlA2 status with overall cardiovascular disease in the general population is significant but weak; higher risk has been identified in less heterogenous subgroups as in the younger cohorts and in the restenosis subset with stents.

Original languageEnglish
Pages (from-to)626-633
Number of pages8
JournalThrombosis and Haemostasis
Volume85
Issue number4
Publication statusPublished - 2001

Keywords

  • Coronary disease
  • Genes
  • Meta-analysis
  • Pl/Pl polymorphism
  • Platelet glycoprotein

ASJC Scopus subject areas

  • Hematology

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