Platelet hyperactivity in hypertensive older patients is controlled by lowering blood pressure

Silvia Riondino, Pasquale Pignatelli, Fabio M. Pulcinelli, Luisa Lenti, Claudio Di Veroli, Vincenzo Marigliano, Pier Paolo Gazzaniga

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: Patients with hypertension tend to have a high prevalence of atherothrombotic accidents. Platelet hyperactivity is frequently associated with hypertension. Because the vascular disease associated with hypertension evolves over the years, we investigated platelet activity parameters in a population of older hypertensive patients with no other risk factors for cardiovascular disease. PARTICIPANTS: We studied 34 older, nonsmoking patients (mean age 74 ± 5 years) with uncomplicated hypertension before and after the normalization of blood pressure (BP) was achieved with the angiotensin-converting enzyme inhibitor quinapril alone or in combination with the Ca2+ antagonist nifedipine. MEASUREMENTS: Platelet aggregation, P- selectin (CD62) expression on the platelet surface, serum levels of Interleukin-1β (IL-1β) and of Interleukin-6 (IL-6), as well as plasma levels of soluble P-selectin and Endothelin-1 (ET-1), were analyzed. RESULTS: All platelet hyperactivity parameters were reduced significantly with the normalization of BP at the end of antihypertensive drug treatment (systolic/diastolic: 186.2 ± 2.7/103.4 ± 1.1 mm Hg vs 135.0 ± 1.3/85.9 ± 1.9 mm Hg; P <.001). Those factors more strictly associated with endothelium injury, such as ET-1 and IL-6, did not show variations. A significant correlation (Spearman Rank test) was observed among all platelet function parameters and blood pressure values. CONCLUSIONS: This study demonstrated that even in a population of older hypertensive patients with no other risk factor for atherogenic disease, normalization of blood pressure induces a significant reduction of the parameters of enhanced platelet hyperactivity independent of the action exerted, at the platelet level, by the antihypertensive drugs.

Original languageEnglish
Pages (from-to)943-947
Number of pages5
JournalJournal of the American Geriatrics Society
Volume47
Issue number8
Publication statusPublished - Aug 1999

Keywords

  • Hypertension
  • Older people
  • Platelets

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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