Abstract
Original language | English |
---|---|
Pages (from-to) | 555 - 560 |
Number of pages | 6 |
Journal | Seminars in Immunology |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 1 2016 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Platelet-mediated modulation of adaptive immunity. / Iannacone, Matteo.
In: Seminars in Immunology, Vol. 28, No. 6, 01.12.2016, p. 555 - 560.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Platelet-mediated modulation of adaptive immunity
AU - Iannacone, Matteo
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Besides being the main cellular effectors of hemostasis, platelets possess a plethora of intracellular mediators (e.g. cytokines, chemokines and antimicrobial molecules) as well as surface receptors (e.g. P-selectin, integrins, CD40L, intercellular adhesion molecule [ICAM]-2, junctional adhesion molecule [JAM]-A, CD44, Toll-like receptors, chemokine receptors) known for their involvement in inflammatory and immune responses. These aspects of platelet biology, which suggest an evolutionary link to a more primitive multifunctional innate defensive cell, position platelets at the interface between coagulation and immunity. Whereas platelet functions in direct antimicrobial defense and in the enhancement of innate immunity are being increasingly recognized, platelet-mediated modulation of adaptive immunity is often underappreciated by the immunological community. By using mouse models of viral hepatitis as a paradigmatic example, we will review here how platelets coordinate adaptive immune responses and suggest possible clinical implications.
AB - Besides being the main cellular effectors of hemostasis, platelets possess a plethora of intracellular mediators (e.g. cytokines, chemokines and antimicrobial molecules) as well as surface receptors (e.g. P-selectin, integrins, CD40L, intercellular adhesion molecule [ICAM]-2, junctional adhesion molecule [JAM]-A, CD44, Toll-like receptors, chemokine receptors) known for their involvement in inflammatory and immune responses. These aspects of platelet biology, which suggest an evolutionary link to a more primitive multifunctional innate defensive cell, position platelets at the interface between coagulation and immunity. Whereas platelet functions in direct antimicrobial defense and in the enhancement of innate immunity are being increasingly recognized, platelet-mediated modulation of adaptive immunity is often underappreciated by the immunological community. By using mouse models of viral hepatitis as a paradigmatic example, we will review here how platelets coordinate adaptive immune responses and suggest possible clinical implications.
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U2 - 10.1016/j.smim.2016.10.008
DO - 10.1016/j.smim.2016.10.008
M3 - Review article
VL - 28
SP - 555
EP - 560
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
IS - 6
ER -