Platelet-Rich Plasma and the Upper Extremity

Allan Mishra, Pietro Randelli, Cameron Barr, Tazio Talamonti, Vincenza Ragone, Paolo Cabitza

Research output: Contribution to journalArticle

Abstract

Platelet-rich plasma (PRP) is a fraction of whole blood containing powerful growth factors and cytokines. Preclinical studies suggest PRP may be useful for tendon repair or regeneration. Clinical investigations have focused on the treatment of chronic lateral epicondylar tendinopathy and rotator cuff pathology. Multiple controlled studies support the use of PRP for chronic tennis elbow. Rotator cuff studies, however, have produced conflicting results based on PRP formulation, surgical technique, and size of tendon tear. This article explores the scientific rational for using PRP, its various formulations, and the emerging clinical data. Future potential applications are also explored.

Original languageEnglish
Pages (from-to)481-491
Number of pages11
JournalHand Clinics
Volume28
Issue number4
DOIs
Publication statusPublished - Nov 2012

Fingerprint

Platelet-Rich Plasma
Upper Extremity
Rotator Cuff
Tendons
Tennis Elbow
Tendinopathy
Regeneration
Intercellular Signaling Peptides and Proteins
Pathology
Cytokines

Keywords

  • Lateral epicondylitis
  • Platelet-rich plasma
  • PRP
  • Rotator cuff repair
  • Tendinopathy
  • Tennis elbow

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Mishra, A., Randelli, P., Barr, C., Talamonti, T., Ragone, V., & Cabitza, P. (2012). Platelet-Rich Plasma and the Upper Extremity. Hand Clinics, 28(4), 481-491. https://doi.org/10.1016/j.hcl.2012.08.008

Platelet-Rich Plasma and the Upper Extremity. / Mishra, Allan; Randelli, Pietro; Barr, Cameron; Talamonti, Tazio; Ragone, Vincenza; Cabitza, Paolo.

In: Hand Clinics, Vol. 28, No. 4, 11.2012, p. 481-491.

Research output: Contribution to journalArticle

Mishra, A, Randelli, P, Barr, C, Talamonti, T, Ragone, V & Cabitza, P 2012, 'Platelet-Rich Plasma and the Upper Extremity', Hand Clinics, vol. 28, no. 4, pp. 481-491. https://doi.org/10.1016/j.hcl.2012.08.008
Mishra A, Randelli P, Barr C, Talamonti T, Ragone V, Cabitza P. Platelet-Rich Plasma and the Upper Extremity. Hand Clinics. 2012 Nov;28(4):481-491. https://doi.org/10.1016/j.hcl.2012.08.008
Mishra, Allan ; Randelli, Pietro ; Barr, Cameron ; Talamonti, Tazio ; Ragone, Vincenza ; Cabitza, Paolo. / Platelet-Rich Plasma and the Upper Extremity. In: Hand Clinics. 2012 ; Vol. 28, No. 4. pp. 481-491.
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