Platelet-rich plasma in orthopaedic applications: Evidence-based recommendations for treatment

Wellington K. Hsu, Allan Mishra, Scott R. Rodeo, Freddie Fu, Michael A. Terry, Pietro Randelli, S. Terry Canale, Frank B. Kelly

Research output: Contribution to journalArticlepeer-review


Autologous platelet-rich plasma (PRP) therapies have seen a dramatic increase in breadth and frequency of use for orthopaedic conditions in the past 5 years. Rich in many growth factors that have important implications in healing, PRP can potentially regenerate tissue via multiple mechanisms. Proposed clinical and surgical applications include spinal fusion, chondropathy, knee osteoarthritis, tendinopathy, acute and chronic soft-tissue injuries, enhancement of healing after ligament reconstruction, and muscle strains. However, for many conditions, there is limited reliable clinical evidence to guide the use of PRP. Furthermore, classification systems and identification of differences among products are needed to understand the implications of variability.

Original languageEnglish
Pages (from-to)739-748
Number of pages10
JournalJournal of the American Academy of Orthopaedic Surgeons
Issue number12
Publication statusPublished - Dec 2012

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Medicine(all)


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