Purpose: To compare the safety and efficacy of two different approaches of platelet-rich plasma (PRP) production methods as intra-articular injection treatment for knee cartilage degenerative lesions and osteoarthritis (OA). Methods: The study involved 144 symptomatic patients affected by cartilage degenerative lesions and OA. Seventy-two patients were treated with 3 injections of platelet concentrate prepared with a single-spinning procedure (PRGF), the other 72 with 3 injections of PRP obtained with a double-spinning approach. The patients were evaluated prospectively at the enrollment and at 2, 6, and 12 months' follow-up with IKDC, EQ-VAS and Tegner scores; adverse events and patient satisfaction were also recorded. Results: Both treatment groups presented a statistically significant improvement in all the scores evaluated at all the follow-up times. Better results were achieved in both groups in younger patients with a lower degree of cartilage degeneration. The comparative analysis showed similar improvements with the two procedures: in particular, IKDC subjective evaluation increased from 45. 0 ± 10. 1 to 59. 0 ± 16. 2, 61. 3 ± 16. 3, and 61. 6 ± 16. 2 at 2, 6, and 12 months in the PRGF group, and from 42. 1 ± 13. 5 to 60. 8 ± 16. 6, 62. 5 ± 19. 9, and 59. 9 ± 20. 0 at 2, 6, and 12 months in the PRP group, respectively. Concerning adverse events, more swelling (P = 0. 03) and pain reaction (P = 0. 0005), were found after PRP injections. Conclusions: Although PRP injections produced more pain and swelling reaction with respect to that produced by PRGF, similar results were found at the follow-up times, with a significant clinical improvement with respect to the basal level. Better results were achieved in younger patients with a low degree of cartilage degeneration. Level of evidence: II.
- Intra-articular injection
ASJC Scopus subject areas
- Orthopedics and Sports Medicine