Platelet serotonin uptake in child neuropsychiatric disorders

C. Ferrarese, A. Doni, E. Quaggio, L. Radaelli, J. Bogacki, L. Missaglia, C. Rottoli, F. Piardi, M. Molteni

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Platelet serotonin uptake has been widely used as peripheral marker of depression in adult patients. However, few studies regarded child neuropsychiatrie disorders, despite the clinical use of uptake inhibitors. We investigated modifications of serotonin uptake in platelets from 30 child neuropsychiatrie patients, aged 7-16, devided, according to the ICD-10, in the following cathegories: Attention Deficit Hyperactivity Disorder (ADHD F90), affective disorders (F 31-34), generalized anxiety disorder (F41.1), social anxiety (F93.2). 10 normal age and sex related children were used as controls. Anxiety, depression and behavioral scales were applied. Serotonin uptake was determined in fresh platelet preparations, using [3H]serotonin, according to the method of Arora and Melzer. Platelet serotonin uptake was decreased by 60% (p

Original languageEnglish
Pages (from-to)141
Number of pages1
JournalItalian Journal of Neurological Sciences
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology


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