Platelet synthesis of cyclooxygenase and lipoxygenase products in type I and type II diabetes

R. Abbate, S. Pinto, A. Panetta, S. Favilla, D. Prisco, R. Paniccia, D. Vanni, G. F. Gensini, G. G. Neri Serneri

Research output: Contribution to journalArticlepeer-review

Abstract

In 24 type I and 22 type II diabetic patients without vascular complications and in 25 controls platelet thromboxane A2 (TxA2) and prostaglandin E2 (PGE2) production (by radioimmunoassay-RIA) and 1-14C arachidonic acid (AA) metabolism (by high pressure liquid chromatography-HPLC) after thrombin stimulation were studied. Platelets both from type I and type II diabetics generated larger amounts of TxB2 (p <0.001) and PGE2 (p2 production from endogenous AA, suggests that the activation of CO is not the only possible mechanism of platelet activation and that probably an increased availability of platelet AA plays an important role in the enhanced platelet aggregation commonly found in diabetics.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalProstaglandins, Leukotrienes and Essential Fatty Acids
Volume31
Issue number1
DOIs
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Physiology

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