Platelet synthesis of cyclooxygenase and lipoxygenase products in type I and type II diabetes

R. Abbate; S. Pinto; A. Panetta; S. Favilla; D. Prisco; R. Paniccia; D. Vanni; G. F. Gensini; G. G. Neri Serneri

doi:10.1016/0952-3278(88)90158-5

Platelet synthesis of cyclooxygenase and lipoxygenase products in type I and type II diabetes

R. Abbate, S. Pinto, A. Panetta, S. Favilla, D. Prisco, R. Paniccia, D. Vanni, G. F. Gensini, G. G. Neri Serneri

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

In 24 type I and 22 type II diabetic patients without vascular complications and in 25 controls platelet thromboxane A2 (TxA2) and prostaglandin E2 (PGE₂) production (by radioimmunoassay-RIA) and 1-14C arachidonic acid (AA) metabolism (by high pressure liquid chromatography-HPLC) after thrombin stimulation were studied. Platelets both from type I and type II diabetics generated larger amounts of TxB2 (p <0.001) and PGE₂ (p2 production from endogenous AA, suggests that the activation of CO is not the only possible mechanism of platelet activation and that probably an increased availability of platelet AA plays an important role in the enhanced platelet aggregation commonly found in diabetics.

Original language	English
Pages (from-to)	9-15
Number of pages	7
Journal	Prostaglandins, Leukotrienes and Essential Fatty Acids
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/0952-3278(88)90158-5
Publication status	Published - 1988

ASJC Scopus subject areas

Clinical Biochemistry
Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Physiology

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Platelet synthesis of cyclooxygenase and lipoxygenase products in type I and type II diabetes. / Abbate, R.; Pinto, S.; Panetta, A.; Favilla, S.; Prisco, D.; Paniccia, R.; Vanni, D.; Gensini, G. F.; Neri Serneri, G. G.

In: Prostaglandins, Leukotrienes and Essential Fatty Acids, Vol. 31, No. 1, 1988, p. 9-15.

Research output: Contribution to journal › Article › peer-review

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abstract = "In 24 type I and 22 type II diabetic patients without vascular complications and in 25 controls platelet thromboxane A2 (TxA2) and prostaglandin E2 (PGE2) production (by radioimmunoassay-RIA) and 1-14C arachidonic acid (AA) metabolism (by high pressure liquid chromatography-HPLC) after thrombin stimulation were studied. Platelets both from type I and type II diabetics generated larger amounts of TxB2 (p <0.001) and PGE2 (p2 production from endogenous AA, suggests that the activation of CO is not the only possible mechanism of platelet activation and that probably an increased availability of platelet AA plays an important role in the enhanced platelet aggregation commonly found in diabetics.",

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AU - Abbate, R.

AU - Pinto, S.

AU - Panetta, A.

AU - Favilla, S.

AU - Prisco, D.

AU - Paniccia, R.

AU - Vanni, D.

AU - Gensini, G. F.

AU - Neri Serneri, G. G.

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AB - In 24 type I and 22 type II diabetic patients without vascular complications and in 25 controls platelet thromboxane A2 (TxA2) and prostaglandin E2 (PGE2) production (by radioimmunoassay-RIA) and 1-14C arachidonic acid (AA) metabolism (by high pressure liquid chromatography-HPLC) after thrombin stimulation were studied. Platelets both from type I and type II diabetics generated larger amounts of TxB2 (p <0.001) and PGE2 (p2 production from endogenous AA, suggests that the activation of CO is not the only possible mechanism of platelet activation and that probably an increased availability of platelet AA plays an important role in the enhanced platelet aggregation commonly found in diabetics.

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Platelet synthesis of cyclooxygenase and lipoxygenase products in type I and type II diabetes

Abstract

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