Platelet thromboxane A2 receptors in habitual smokers

P. A. Modesti, R. Abbate, G. F. Gensini, A. Colella, G. G. Neri Serneri

Research output: Contribution to journalArticlepeer-review

Abstract

Cigarette smoking is a major risk factor for cardiovascular disease but its effect on platelet aggregability and particularly on TxA2 platelet metabolism is controversial. In present study TxA2 platelet receptors of 8 male clinically healthy habitual smokers (more than 20 cig./day) aged 30-55 (44±6 years) and of 9 age matched healthy controls were evaluated. Platelet TxA2 receptors were investigated by a radioligand binding method employing 125I-PTA-OH, a radioiodinated hydroxy derivative of the 13-azapinane thromboxane antagonist (ONO11120). Binding studies evidentiated a single class of specific high affinity receptors for the TxA2 analogue. In non smokers 990+220 receptors/platelet (rec/plt) with a dissociation constant (kd) of 22±11 nM were found. Smokers had a significantly larger number of TxA2 platelet receptors (1268±190 rec/plt p

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalThrombosis Research
Volume55
Issue number2
DOIs
Publication statusPublished - Jul 15 1989

Keywords

  • binding
  • platelet
  • receptor
  • smoking habits
  • thromboxane A2

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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