Abstract

Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.

Original languageEnglish
Article number1568
JournalCancers
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

Fingerprint

Liver Neoplasms
Blood Platelets
Neoplasms
Endothelial Growth Factors
Platelet-Derived Growth Factor
Platelet Count
Vascular Endothelial Growth Factor A
Endothelium
Serotonin
Cell Survival
Intercellular Signaling Peptides and Proteins
Growth
Therapeutics

Keywords

  • Integrins
  • Platelet-derived growth factor
  • Platelet-to-lymphocyte ratio
  • Selectins
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group (2019). Platelets and hepatocellular cancer: Bridging the bench to the clinics. Cancers, 11(10), [1568]. https://doi.org/10.3390/cancers11101568

Platelets and hepatocellular cancer : Bridging the bench to the clinics. / Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group.

In: Cancers, Vol. 11, No. 10, 1568, 01.10.2019.

Research output: Contribution to journalReview article

Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group 2019, 'Platelets and hepatocellular cancer: Bridging the bench to the clinics', Cancers, vol. 11, no. 10, 1568. https://doi.org/10.3390/cancers11101568
Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group. Platelets and hepatocellular cancer: Bridging the bench to the clinics. Cancers. 2019 Oct 1;11(10). 1568. https://doi.org/10.3390/cancers11101568
Associazione Italiana per lo Studio del Fegato (AISF) HCC Special Interest Group. / Platelets and hepatocellular cancer : Bridging the bench to the clinics. In: Cancers. 2019 ; Vol. 11, No. 10.
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abstract = "Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.",
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AU - Manzia, Tommaso M.

AU - Foschi, Francesco G.

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AU - Conti, F.

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AU - Di Sandro, S.

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AB - Growing interest is recently being focused on the role played by the platelets in favoring hepatocellular cancer (HCC) growth and dissemination. The present review reports in detail both the experimental and clinical evidence published on this topic. Several growth factors and angiogenic molecules specifically secreted by platelets are directly connected with tumor progression and neo-angiogenesis. Among them, we can list the platelet-derived growth factor, the vascular endothelial growth factor, the endothelial growth factor, and serotonin. Platelets are also involved in tumor spread, favoring endothelium permeabilization and tumor cells’ extravasation and survival in the bloodstream. From the bench to the clinics, all of these aspects were also investigated in clinical series, showing an evident correlation between platelet count and size of HCC, tumor biological behavior, metastatic spread, and overall survival rates. Moreover, a better understanding of the mechanisms involved in the platelet–tumor axis represents a paramount aspect for optimizing both current tumor treatment and development of new therapeutic strategies against HCC.

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