TY - JOUR
T1 - Platelets Cellular and Functional Characteristics in Patients with Atrial Fibrillation
T2 - A Comprehensive Meta-Analysis and Systematic Review
AU - Weymann, Alexander
AU - Ali-Hasan-Al-Saegh, Sadeq
AU - Sabashnikov, Anton
AU - Popov, Aron-Frederik
AU - Mirhosseini, Seyed Jalil
AU - Nombela-Franco, Luis
AU - Testa, Luca
AU - Lotfaliani, Mohammadreza
AU - Zeriouh, Mohamed
AU - Liu, Tong
AU - Dehghan, Hamidreza
AU - Yavuz, Senol
AU - de Oliveira Sá, Michel Pompeu Barros
AU - Baker, William L
AU - Jang, Jae-Sik
AU - Gong, Mengqi
AU - Benedetto, Umberto
AU - Dohmen, Pascal M
AU - D'Ascenzo, Fabrizio
AU - Deshmukh, Abhishek J
AU - Biondi-Zoccai, Giuseppe
AU - Calkins, Hugh
AU - Stone, Gregg W
AU - Surgery And Cardiology-Group Imcsc-Group, Integrated Meta-Analysis Of Cardiac
PY - 2017/3/17
Y1 - 2017/3/17
N2 - BACKGROUND This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution width (PDW), platelet factor 4, beta thromboglobulin (BTG), and p-selectin with the occurrence of atrial fibrillation (AF) and consequent stroke. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating platelet characteristics in patients with paroxysmal, persistent and permanent atrial fibrillations. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS Literature search of all major databases retrieved 1,676 studies. After screening, a total of 73 studies were identified. Pooled analysis showed significant differences in PC (weighted mean difference (WMD)=-26.93 and p<0.001), MPV (WMD=0.61 and p<0.001), PDW (WMD=-0.22 and p=0.002), BTG (WMD=24.69 and p<0.001), PF4 (WMD=4.59 and p<0.001), and p-selectin (WMD=4.90 and p<0.001). CONCLUSIONS Platelets play a critical and precipitating role in the occurrence of AF. Whereas distribution width of platelets as well as factors of platelet activity was significantly greater in AF patients compared to SR patients, platelet count was significantly lower in AF patients.
AB - BACKGROUND This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of platelet cellular and functional characteristics including platelet count (PC), MPV, platelet distribution width (PDW), platelet factor 4, beta thromboglobulin (BTG), and p-selectin with the occurrence of atrial fibrillation (AF) and consequent stroke. MATERIAL AND METHODS We conducted a meta-analysis of observational studies evaluating platelet characteristics in patients with paroxysmal, persistent and permanent atrial fibrillations. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity. RESULTS Literature search of all major databases retrieved 1,676 studies. After screening, a total of 73 studies were identified. Pooled analysis showed significant differences in PC (weighted mean difference (WMD)=-26.93 and p<0.001), MPV (WMD=0.61 and p<0.001), PDW (WMD=-0.22 and p=0.002), BTG (WMD=24.69 and p<0.001), PF4 (WMD=4.59 and p<0.001), and p-selectin (WMD=4.90 and p<0.001). CONCLUSIONS Platelets play a critical and precipitating role in the occurrence of AF. Whereas distribution width of platelets as well as factors of platelet activity was significantly greater in AF patients compared to SR patients, platelet count was significantly lower in AF patients.
KW - Atrial Fibrillation
KW - Blood Coagulation
KW - Blood Platelets
KW - Humans
KW - Platelet Activation
KW - Platelet Count
KW - Stroke
KW - Journal Article
KW - Meta-Analysis
KW - Review
M3 - Review article
C2 - 28302997
VL - 23
SP - 58
EP - 86
JO - Medical science monitor basic research
JF - Medical science monitor basic research
SN - 2325-4394
ER -