Platelets from uraemic patients react normally to prostacyclin

F. Pusineri; E. Gotti; G. Remuzzi; G. Mecca; M. B. Donati; G. de Gaetano

Platelets from uraemic patients react normally to prostacyclin

F. Pusineri, E. Gotti, G. Remuzzi, G. Mecca, M. B. Donati, G. de Gaetano

Research output: Contribution to journal › Article › peer-review

Abstract

We measured the minimal concentrations of synthetic prostacyclin required to inhibit completely in vitro platelet aggregation induced by threshold concentrations of ADP or arachidonic acid. No significant differences were found (with Student's t test for paired comparisons) between the amounts of prostacyclin required to inhibit aggregation of platelets from 10 uremic patiens (on long term hemodialysis) and 10 controls. This indicates that exogenous prostacyclin may impair platelet function in hemodialysed patients.

Original language	English
Pages (from-to)	125
Number of pages	1
Journal	International Journal of Artificial Organs
Volume	3
Issue number	2
Publication status	Published - 1980

ASJC Scopus subject areas

Biophysics

Cite this

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abstract = "We measured the minimal concentrations of synthetic prostacyclin required to inhibit completely in vitro platelet aggregation induced by threshold concentrations of ADP or arachidonic acid. No significant differences were found (with Student's t test for paired comparisons) between the amounts of prostacyclin required to inhibit aggregation of platelets from 10 uremic patiens (on long term hemodialysis) and 10 controls. This indicates that exogenous prostacyclin may impair platelet function in hemodialysed patients.",

author = "F. Pusineri and E. Gotti and G. Remuzzi and G. Mecca and Donati, {M. B.} and {de Gaetano}, G.",

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AU - Pusineri, F.

AU - Gotti, E.

AU - Remuzzi, G.

AU - Mecca, G.

AU - Donati, M. B.

AU - de Gaetano, G.

PY - 1980

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N2 - We measured the minimal concentrations of synthetic prostacyclin required to inhibit completely in vitro platelet aggregation induced by threshold concentrations of ADP or arachidonic acid. No significant differences were found (with Student's t test for paired comparisons) between the amounts of prostacyclin required to inhibit aggregation of platelets from 10 uremic patiens (on long term hemodialysis) and 10 controls. This indicates that exogenous prostacyclin may impair platelet function in hemodialysed patients.

AB - We measured the minimal concentrations of synthetic prostacyclin required to inhibit completely in vitro platelet aggregation induced by threshold concentrations of ADP or arachidonic acid. No significant differences were found (with Student's t test for paired comparisons) between the amounts of prostacyclin required to inhibit aggregation of platelets from 10 uremic patiens (on long term hemodialysis) and 10 controls. This indicates that exogenous prostacyclin may impair platelet function in hemodialysed patients.

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Platelets from uraemic patients react normally to prostacyclin

Abstract

ASJC Scopus subject areas

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