Platelets mediate cytotoxic T lymphocyte-induced liver damage

Matteo Iannacone, Giovanni Sitia, Masanori Isogawa, Patrizia Marchese, Maria G. Castro, Pedro R. Lowenstein, Francis V. Chisari, Zaverio M. Ruggeri, Luca G. Guidotti

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

Original languageEnglish
Pages (from-to)1167-1169
Number of pages3
JournalNature Medicine
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2005

Fingerprint

T-cells
Cytotoxic T-Lymphocytes
Platelets
Liver
Blood Platelets
Platelet Activation
Fibrin
Platelet Count
Anticoagulants
Hepatitis
Viruses
Wounds and Injuries
Chemical activation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Platelets mediate cytotoxic T lymphocyte-induced liver damage. / Iannacone, Matteo; Sitia, Giovanni; Isogawa, Masanori; Marchese, Patrizia; Castro, Maria G.; Lowenstein, Pedro R.; Chisari, Francis V.; Ruggeri, Zaverio M.; Guidotti, Luca G.

In: Nature Medicine, Vol. 11, No. 11, 11.2005, p. 1167-1169.

Research output: Contribution to journalArticle

Iannacone, M, Sitia, G, Isogawa, M, Marchese, P, Castro, MG, Lowenstein, PR, Chisari, FV, Ruggeri, ZM & Guidotti, LG 2005, 'Platelets mediate cytotoxic T lymphocyte-induced liver damage', Nature Medicine, vol. 11, no. 11, pp. 1167-1169. https://doi.org/10.1038/nm1317
Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR et al. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nature Medicine. 2005 Nov;11(11):1167-1169. https://doi.org/10.1038/nm1317
Iannacone, Matteo ; Sitia, Giovanni ; Isogawa, Masanori ; Marchese, Patrizia ; Castro, Maria G. ; Lowenstein, Pedro R. ; Chisari, Francis V. ; Ruggeri, Zaverio M. ; Guidotti, Luca G. / Platelets mediate cytotoxic T lymphocyte-induced liver damage. In: Nature Medicine. 2005 ; Vol. 11, No. 11. pp. 1167-1169.
@article{9a359346537f4af4b23db6c82f0ceb4c,
title = "Platelets mediate cytotoxic T lymphocyte-induced liver damage",
abstract = "We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.",
author = "Matteo Iannacone and Giovanni Sitia and Masanori Isogawa and Patrizia Marchese and Castro, {Maria G.} and Lowenstein, {Pedro R.} and Chisari, {Francis V.} and Ruggeri, {Zaverio M.} and Guidotti, {Luca G.}",
year = "2005",
month = "11",
doi = "10.1038/nm1317",
language = "English",
volume = "11",
pages = "1167--1169",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Platelets mediate cytotoxic T lymphocyte-induced liver damage

AU - Iannacone, Matteo

AU - Sitia, Giovanni

AU - Isogawa, Masanori

AU - Marchese, Patrizia

AU - Castro, Maria G.

AU - Lowenstein, Pedro R.

AU - Chisari, Francis V.

AU - Ruggeri, Zaverio M.

AU - Guidotti, Luca G.

PY - 2005/11

Y1 - 2005/11

N2 - We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

AB - We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

UR - http://www.scopus.com/inward/record.url?scp=30744437415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30744437415&partnerID=8YFLogxK

U2 - 10.1038/nm1317

DO - 10.1038/nm1317

M3 - Article

C2 - 16258538

AN - SCOPUS:30744437415

VL - 11

SP - 1167

EP - 1169

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 11

ER -