Platelets mediate cytotoxic T lymphocyte-induced liver damage

Matteo Iannacone, Giovanni Sitia, Masanori Isogawa, Patrizia Marchese, Maria G. Castro, Pedro R. Lowenstein, Francis V. Chisari, Zaverio M. Ruggeri, Luca G. Guidotti

Research output: Contribution to journalArticle

Abstract

We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.

Original languageEnglish
Pages (from-to)1167-1169
Number of pages3
JournalNature Medicine
Volume11
Issue number11
DOIs
Publication statusPublished - Nov 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Iannacone, M., Sitia, G., Isogawa, M., Marchese, P., Castro, M. G., Lowenstein, P. R., Chisari, F. V., Ruggeri, Z. M., & Guidotti, L. G. (2005). Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nature Medicine, 11(11), 1167-1169. https://doi.org/10.1038/nm1317