Pleiotropic Role of Notch Signaling in Human Skin Diseases

Rossella Gratton, Paola Maura Tricarico, Chiara Moltrasio, Ana Sofia Lima Estevão de Oliveira, Lucas Brandão, Angelo Valerio Marzano, Luisa Zupin, Sergio Crovella

Research output: Contribution to journalReview articlepeer-review


Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling route, might lead to both hyper- or hypo-activation of Notch signaling molecules and of target genes, ultimately inducing the onset of skin diseases. The mechanisms through which Notch contributes to the pathogenesis of skin diseases are multiple and still not fully understood. So far, Notch signaling alterations have been reported for five human skin diseases, suggesting the involvement of Notch in their pathogenesis: Hidradenitis Suppurativa, Dowling Degos Disease, Adams-Oliver Syndrome, Psoriasis and Atopic Dermatitis. In this review, we aim at describing the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in these five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.

Original languageEnglish
Article number4214
JournalInternational Journal of Molecular Sciences
Issue number12
Publication statusPublished - Jun 13 2020


  • differentiation
  • Notch pathway
  • proliferation
  • skin disorder

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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