TY - JOUR
T1 - Pleiotropic Role of Notch Signaling in Human Skin Diseases
AU - Gratton, Rossella
AU - Tricarico, Paola Maura
AU - Moltrasio, Chiara
AU - Lima Estevão de Oliveira, Ana Sofia
AU - Brandão, Lucas
AU - Marzano, Angelo Valerio
AU - Zupin, Luisa
AU - Crovella, Sergio
N1 - M1 - 4214
PY - 2020/6/13
Y1 - 2020/6/13
N2 - Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling route, might lead to both hyper- or hypo-activation of Notch signaling molecules and of target genes, ultimately inducing the onset of skin diseases. The mechanisms through which Notch contributes to the pathogenesis of skin diseases are multiple and still not fully understood. So far, Notch signaling alterations have been reported for five human skin diseases, suggesting the involvement of Notch in their pathogenesis: Hidradenitis Suppurativa, Dowling Degos Disease, Adams-Oliver Syndrome, Psoriasis and Atopic Dermatitis. In this review, we aim at describing the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in these five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.
AB - Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling route, might lead to both hyper- or hypo-activation of Notch signaling molecules and of target genes, ultimately inducing the onset of skin diseases. The mechanisms through which Notch contributes to the pathogenesis of skin diseases are multiple and still not fully understood. So far, Notch signaling alterations have been reported for five human skin diseases, suggesting the involvement of Notch in their pathogenesis: Hidradenitis Suppurativa, Dowling Degos Disease, Adams-Oliver Syndrome, Psoriasis and Atopic Dermatitis. In this review, we aim at describing the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in these five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.
KW - differentiation
KW - Notch pathway
KW - proliferation
KW - skin disorder
U2 - 10.3390/ijms21124214
DO - 10.3390/ijms21124214
M3 - Article
VL - 21
JO - Int. J. Mol. Sci.
JF - Int. J. Mol. Sci.
SN - 1661-6596
IS - 12
ER -