We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.
|Number of pages||6|
|Publication status||Published - Jun 1 2003|
- Pleomorph tumor
- Poorly differentiated endocrine carcinoma
ASJC Scopus subject areas
- Pathology and Forensic Medicine