Pleomorph poorly differentiated endocrine carcinoma of the rectum

Pellegrino Crafa, Massimo Milione, Cinzia Azzoni, Francesco Paolo Pilato, Silvia Pizzi, Cesare Bordi

Research output: Contribution to journalArticlepeer-review

Abstract

We present a case of poorly differentiated endocrine carcinoma (PDEC) of the rectum identified immunohistochemically and characterized by a high degree of cellular pleomorphism, including bizarre giant cells. This case indicates that gastrointestinal PDECs are not restricted to small cell carcinomas. Among the multiple genes investigated, loss of heterozygosity (LOH) of the p53 locus without p53 immohistochemical accumulation, overexpression of c-kit and absent expression of p16 were seen.

Original languageEnglish
Pages (from-to)605-610
Number of pages6
JournalVirchows Archiv
Volume442
Issue number6
Publication statusPublished - Jun 1 2003

Keywords

  • Pleomorph tumor
  • Poorly differentiated endocrine carcinoma
  • Rectum

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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