Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib: Case report

Alberto Bongiovanni; Marianna Ricci; Nada Riva; Sebastiano Calpona; Devil Oboldi; Federica Pieri; Davide Cavaliere; Laura Mercatali; Chiara Liverani; Federico La Manna; Alessandro De Vita; Flavia Foca; Erica Gunelli; Dino Amadori; Toni Ibrahim

doi:10.2217/fon.14.159

Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib: Case report

Alberto Bongiovanni, Marianna Ricci, Nada Riva, Sebastiano Calpona, Devil Oboldi, Federica Pieri, Davide Cavaliere, Laura Mercatali, Chiara Liverani, Federico La Manna, Alessandro De Vita, Flavia Foca, Erica Gunelli, Dino Amadori, Toni Ibrahim

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

Gastrointestinal stromal tumors are rare malignancies characterized by c-kit and PDGFR-α mutations targeted by imatinib. Pleural effusion is a very rare side effect of imatinib treatment. A 65-year-old female with metastatic gastrointestinal stromal tumor developed electrolyte imbalance, severe peripheral edema and progressively worsening dyspnea 2 months after starting imatinib. Having excluded cardiovascular and pulmonary disorders, imatinib was discontinued and prednisone 25 mg orally daily was begun. The patient's condition improved substantially over the next 48 h with a progressive decrease in dyspnea and a reduction in pleural effusion and peripheral edema. All side effects had resolved within 1 month. In view of the partial response obtained, the patient re-started imatinib after a 1-week interruption. Prednisone was maintained and there was no further toxicity.

Original language	English
Pages (from-to)	2423-2427
Number of pages	5
Journal	Future Oncology
Volume	10
Issue number	15
DOIs	https://doi.org/10.2217/fon.14.159
Publication status	Published - Dec 1 2014

Keywords

gastrointestinal stromal tumor
imatinib
metastatic gastrointestinal stromal tumor
pleural effusion
toxicity

ASJC Scopus subject areas

Oncology
Cancer Research

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10.2217/fon.14.159

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Bongiovanni, A., Ricci, M., Riva, N., Calpona, S., Oboldi, D., Pieri, F., Cavaliere, D., Mercatali, L., Liverani, C., La Manna, F., De Vita, A., Foca, F., Gunelli, E., Amadori, D., & Ibrahim, T. (2014). Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib: Case report. Future Oncology, 10(15), 2423-2427. https://doi.org/10.2217/fon.14.159

Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib : Case report. / Bongiovanni, Alberto; Ricci, Marianna; Riva, Nada; Calpona, Sebastiano; Oboldi, Devil; Pieri, Federica; Cavaliere, Davide; Mercatali, Laura ; Liverani, Chiara; La Manna, Federico; De Vita, Alessandro ; Foca, Flavia; Gunelli, Erica; Amadori, Dino; Ibrahim, Toni.

In: Future Oncology, Vol. 10, No. 15, 01.12.2014, p. 2423-2427.

Research output: Contribution to journal › Article › peer-review

Bongiovanni, A, Ricci, M, Riva, N, Calpona, S, Oboldi, D, Pieri, F, Cavaliere, D, Mercatali, L , Liverani, C, La Manna, F, De Vita, A , Foca, F, Gunelli, E, Amadori, D & Ibrahim, T 2014, 'Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib: Case report', Future Oncology, vol. 10, no. 15, pp. 2423-2427. https://doi.org/10.2217/fon.14.159

Bongiovanni, Alberto ; Ricci, Marianna ; Riva, Nada ; Calpona, Sebastiano ; Oboldi, Devil ; Pieri, Federica ; Cavaliere, Davide ; Mercatali, Laura ; Liverani, Chiara ; La Manna, Federico ; De Vita, Alessandro ; Foca, Flavia ; Gunelli, Erica ; Amadori, Dino ; Ibrahim, Toni. / Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib : Case report. In: Future Oncology. 2014 ; Vol. 10, No. 15. pp. 2423-2427.

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AU - De Vita, Alessandro

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AU - Gunelli, Erica

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Pleural effusion in a patient with metastatic gastrointestinal stromal tumor treated with imatinib: Case report

Abstract

Keywords

ASJC Scopus subject areas

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