TY - JOUR
T1 - Pleural malignant mesothelioma epidemic
T2 - Incidence, modalities of asbestos exposure and occupations involved from the Italian National Register
AU - Marinaccio, Alessandro
AU - Binazzi, Alessandra
AU - Marzio, Davide Di
AU - Scarselli, Alberto
AU - Verardo, Marina
AU - Mirabelli, Dario
AU - Gennaro, Valerio
AU - Mensi, Carolina
AU - Riboldi, Luciano
AU - Merler, Enzo
AU - Zotti, Renata De
AU - Romanelli, Antonio
AU - Chellini, Elisabetta
AU - Silvestri, Stefano
AU - Pascucci, Cristiana
AU - Romeo, Elisa
AU - Menegozzo, Simona
AU - Musti, Marina
AU - Cavone, Domenica
AU - Cauzillo, Gabriella
AU - Tumino, Rosario
AU - Nicita, Carmela
AU - Melis, Massimo
AU - Iavicoli, Sergio
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004, a case-list of 8,868 pleural MM was recorded by the Italian National Register (ReNaM) and the modalities of exposure to asbestos fibres have been investigated for 6,603 of them. Standardized incidence rates are 3.49 (per 100,000 inhabitants) for men and 1.25 for women, with a wide regional variability. Occupational asbestos exposure was in 69.3% of interviewed subjects (N = 4,577 cases), while 4.4% was due to cohabitation with someone (generally, the husband) occupationally exposed, 4.7% by environmental exposure from living near a contamination source and 1.6% during a leisure activity. In the male group, 81.5% of interviewed subjects exhibit an occupational exposure. In the exposed workers, the median year of first exposure was 1957, and mean latency was 43.7 years. The analysis of exposures by industrial sector focuses on a decreasing trend for those traditionally signaled as "at risk" (asbestos-cement industry, shipbuilding and repair and railway carriages maintenance) and an increasing trend for the building construction sector. The systematic mesothelioma surveillance system is relevant for the prevention of the disease and for supporting an efficient compensation system. The existing experience on all-too-predictable asbestos effects should be transferred to developing countries where asbestos use is spreading.
AB - Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004, a case-list of 8,868 pleural MM was recorded by the Italian National Register (ReNaM) and the modalities of exposure to asbestos fibres have been investigated for 6,603 of them. Standardized incidence rates are 3.49 (per 100,000 inhabitants) for men and 1.25 for women, with a wide regional variability. Occupational asbestos exposure was in 69.3% of interviewed subjects (N = 4,577 cases), while 4.4% was due to cohabitation with someone (generally, the husband) occupationally exposed, 4.7% by environmental exposure from living near a contamination source and 1.6% during a leisure activity. In the male group, 81.5% of interviewed subjects exhibit an occupational exposure. In the exposed workers, the median year of first exposure was 1957, and mean latency was 43.7 years. The analysis of exposures by industrial sector focuses on a decreasing trend for those traditionally signaled as "at risk" (asbestos-cement industry, shipbuilding and repair and railway carriages maintenance) and an increasing trend for the building construction sector. The systematic mesothelioma surveillance system is relevant for the prevention of the disease and for supporting an efficient compensation system. The existing experience on all-too-predictable asbestos effects should be transferred to developing countries where asbestos use is spreading.
KW - asbestos
KW - Italy
KW - mesothelioma
KW - national register
KW - pleural
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U2 - 10.1002/ijc.26229
DO - 10.1002/ijc.26229
M3 - Article
C2 - 21647880
AN - SCOPUS:84857504063
VL - 130
SP - 2146
EP - 2154
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 9
ER -