Pleural malignant solitary fibrous tumors (SFTs) are uncommon, and little is known about their histogenesis and molecular features. We report a case of pleural SFT with sarcomatous overgrowth that showed expression for PDGFRβ and a missense mutation on exon 18 of the PDGFRβ gene. The involvement of the PDGFRβ gene in SFT is compatible with a pericytic derivation, also supporting a possible role of this tyrosine kinase in malignant transformation and in the adoption of novel molecular therapies.
- Molecular biology
- Tumor markers
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine