Pleural malignant solitary fibrous tumor with sarcomatous overgrowth showing PDGFRβ mutation

Giulio Rossi, Laura Schirosi, Filippo Giovanardi, Giuliana Sartori, Massimiliano Paci, Alberto Cavazza

Research output: Contribution to journalArticle

Abstract

Pleural malignant solitary fibrous tumors (SFTs) are uncommon, and little is known about their histogenesis and molecular features. We report a case of pleural SFT with sarcomatous overgrowth that showed expression for PDGFRβ and a missense mutation on exon 18 of the PDGFRβ gene. The involvement of the PDGFRβ gene in SFT is compatible with a pericytic derivation, also supporting a possible role of this tyrosine kinase in malignant transformation and in the adoption of novel molecular therapies.

Original languageEnglish
Pages (from-to)581-583
Number of pages3
JournalChest
Volume130
Issue number2
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Molecular biology
  • Oncology
  • Surgery
  • Tumor markers

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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