Pleuro-pulmonary solitary fibrous tumors: A clinicopathologic, immunohistochemical, and molecular study of 88 cases confirming the prognostic value of de perrot staging system and p53 expression, and evaluating the role of c-kit, BRAF, PDGFRs (α/β), c-met, and EGFR

Laura Schirosi, Sylvie Lantuejoul, Alberto Cavazza, Bruno Murer, Pierre Yves Brichon, Mario Migaldi, Giuliana Sartori, Alessandro Sgambato, Giulio Rossi

Research output: Contribution to journalArticlepeer-review

Abstract

Pleuro-pulmonary solitary fibrous tumor (SFT) is a relatively uncommon mesenchymal neoplasm of uncertain histogenesis, unknown molecular features, and unpredictable clinical behavior. Although complete resection is universally accepted as the most important single prognostic factor, some clinicopathologic characteristics (gross appearance, tumor size, mitotic index, tumor necrosis, hypercellularity, and pleomorphism) are related to patient outcome, and a staging system based on these parameters with practical therapeutical implications has been recently proposed by de Perrot et al. Here, 88 pleuro-pulmonary SFTs were collected and clinicopathologic characteristics including de Perrot classification, patients follow-up, p53 expression, and several "targetable" kinases [c-kit, v-raf murine sarcoma viral oncogene homolog B1, platelet-derived growth factor receptor (PDGFR)-α/β, c-met, epidermal growth factor receptor (EGFR)] were retrospectively analyzed. Fifty-two cases (59%) had at least 1 clinicopathologic feature related to malignancy, whereas mortality and recurrences occurred in 10.2% and 18.2% of the cases, respectively. de Perrot staging and high p53 expression were significantly related to the conventional clinicopathologic prognostic features as well as to overall survival (OS) and disease-free survival (DFS) (P

Original languageEnglish
Pages (from-to)1627-1642
Number of pages16
JournalAmerican Journal of Surgical Pathology
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 2008

Keywords

  • C-met
  • P53
  • PDGFR
  • Solitary fibrous tumor
  • Stage
  • Tyrosine kinases

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

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