Plexin-B3 is a functional receptor for semaphorin 5A

Stefania Artigiani, Paolo Conrotto, Pietro Fazzari, Giorgio F. Gilestro, Davide Barberis, Silvia Giordano, Paolo M. Comoglio, Luca Tamagnone

Research output: Contribution to journalArticlepeer-review

Abstract

Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). in addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3.

Original languageEnglish
Pages (from-to)710-714
Number of pages5
JournalEMBO Reports
Volume5
Issue number7
DOIs
Publication statusPublished - Jul 2004

Keywords

  • Axon guidance
  • Cell migration
  • HGF
  • Met
  • Plexin
  • Semaphorin

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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