Abstract
Integrin the are major extracellular matrix receptors and their functional state with respect to the affinity for extracellular matrix proteins is pivotal for their biological activities in physiologic and pathological settings. Integrins' machinery depends on the dynamic regulation of their adhesive function in space and time. In cells, integrins exist in different conformations which determine their affinity for extracellular matrix proteins and are continuously endocytosed, trafficked through endosomal compartments, and recycled back to the plasma membrane. Therefore real-time modulation of cell - extracellular matrix adhesion can result from two interconnected phenomena: the regulation of integrin conformation and traffic in response to extracellular stimuli. This review summarizes recent data highlighting the different mechanisms by which semaphorins and their receptors plexins and neuropilins regulate integrin functions in vascular system. Domenico Ribatti (Ed.) All rights reserved -
| Original language | English |
|---|---|
| Title of host publication | Recent Advances in Angiogenesis and Antiangiogenesis |
| Publisher | Bentham Science Publishers Ltd. |
| Pages | 1-9 |
| Number of pages | 9 |
| ISBN (Print) | 9781608056934 |
| DOIs | |
| Publication status | Published - 2009 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Plexins and neuropilins regulate integrin conformation and trafficking in endothelial cells. / Serini, Guido; Valdembri, Donatella; Bussolino, Federico.
Recent Advances in Angiogenesis and Antiangiogenesis. Bentham Science Publishers Ltd., 2009. p. 1-9.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Plexins and neuropilins regulate integrin conformation and trafficking in endothelial cells
AU - Serini, Guido
AU - Valdembri, Donatella
AU - Bussolino, Federico
PY - 2009
Y1 - 2009
N2 - Integrin the are major extracellular matrix receptors and their functional state with respect to the affinity for extracellular matrix proteins is pivotal for their biological activities in physiologic and pathological settings. Integrins' machinery depends on the dynamic regulation of their adhesive function in space and time. In cells, integrins exist in different conformations which determine their affinity for extracellular matrix proteins and are continuously endocytosed, trafficked through endosomal compartments, and recycled back to the plasma membrane. Therefore real-time modulation of cell - extracellular matrix adhesion can result from two interconnected phenomena: the regulation of integrin conformation and traffic in response to extracellular stimuli. This review summarizes recent data highlighting the different mechanisms by which semaphorins and their receptors plexins and neuropilins regulate integrin functions in vascular system. Domenico Ribatti (Ed.) All rights reserved -
AB - Integrin the are major extracellular matrix receptors and their functional state with respect to the affinity for extracellular matrix proteins is pivotal for their biological activities in physiologic and pathological settings. Integrins' machinery depends on the dynamic regulation of their adhesive function in space and time. In cells, integrins exist in different conformations which determine their affinity for extracellular matrix proteins and are continuously endocytosed, trafficked through endosomal compartments, and recycled back to the plasma membrane. Therefore real-time modulation of cell - extracellular matrix adhesion can result from two interconnected phenomena: the regulation of integrin conformation and traffic in response to extracellular stimuli. This review summarizes recent data highlighting the different mechanisms by which semaphorins and their receptors plexins and neuropilins regulate integrin functions in vascular system. Domenico Ribatti (Ed.) All rights reserved -
UR - http://www.scopus.com/inward/record.url?scp=84884466365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884466365&partnerID=8YFLogxK
U2 - 10.2174/978160805004810901011
DO - 10.2174/978160805004810901011
M3 - Chapter
AN - SCOPUS:84884466365
SN - 9781608056934
SP - 1
EP - 9
BT - Recent Advances in Angiogenesis and Antiangiogenesis
PB - Bentham Science Publishers Ltd.
ER -