PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients

Bruno Vincenzi; Daniele Santini; Giuseppe Perrone; Francesco Graziano; Fotios Loupakis; Gaia Schiavon; Anna Maria Frezza; Anna Maria Ruzzo; Sergio Rizzo; Pierfilippo Crucitti; Sara Galluzzo; Alice Zoccoli; Carla Rabitti; Andrea Onetti Muda; Antonio Russo; Alfredo Falcone; Giuseppe Tonini

doi:10.1002/jcp.22801

PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients

Bruno Vincenzi, Daniele Santini, Giuseppe Perrone, Francesco Graziano, Fotios Loupakis, Gaia Schiavon, Anna Maria Frezza, Anna Maria Ruzzo, Sergio Rizzo, Pierfilippo Crucitti, Sara Galluzzo, Alice Zoccoli, Carla Rabitti, Andrea Onetti Muda, Antonio Russo, Alfredo Falcone, Giuseppe Tonini

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

PML regulates a wide range of pathways involved in tumorigenesis, such as apoptosis, which is also one of the main mechanisms through which oxaliplatin and fluoropyrimidine exert their antineoplastic activity. The present study aims to investigate PML expression as a predictive factor of oxaliplatin/fluoropyrimidine therapy efficacy. Seventy-four metastatic colorectal cancer patients who received oxaliplatin/floropyrimidine-based first line therapy have been included in this retrospective study. PML expression was assessed by immunohistochemistry. PML down-regulation was detected in 39 (52.7%) patients (14 complete and 25 partial PML loss). RR was significantly lower (25.6%) in patients with PML down-regulation than in patients with preserved PML expression (60%) (P=0.006). Median TTP was 5.5 months when PML was down-regulated versus 11.9 months in case of preserved PML expression (P

Original language	English
Pages (from-to)	927-933
Number of pages	7
Journal	Journal of Cellular Physiology
Volume	227
Issue number	3
DOIs	https://doi.org/10.1002/jcp.22801
Publication status	Published - Mar 2012

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology
Physiology

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Vincenzi, B., Santini, D., Perrone, G., Graziano, F., Loupakis, F., Schiavon, G., Frezza, A. M., Ruzzo, A. M., Rizzo, S., Crucitti, P., Galluzzo, S., Zoccoli, A., Rabitti, C., Muda, A. O., Russo, A., Falcone, A., & Tonini, G. (2012). PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients. Journal of Cellular Physiology, 227(3), 927-933. https://doi.org/10.1002/jcp.22801

PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients. / Vincenzi, Bruno; Santini, Daniele; Perrone, Giuseppe; Graziano, Francesco; Loupakis, Fotios; Schiavon, Gaia; Frezza, Anna Maria; Ruzzo, Anna Maria; Rizzo, Sergio; Crucitti, Pierfilippo; Galluzzo, Sara; Zoccoli, Alice; Rabitti, Carla; Muda, Andrea Onetti; Russo, Antonio; Falcone, Alfredo; Tonini, Giuseppe.

In: Journal of Cellular Physiology, Vol. 227, No. 3, 03.2012, p. 927-933.

Research output: Contribution to journal › Article › peer-review

Vincenzi, B, Santini, D, Perrone, G, Graziano, F, Loupakis, F, Schiavon, G, Frezza, AM, Ruzzo, AM, Rizzo, S, Crucitti, P, Galluzzo, S, Zoccoli, A, Rabitti, C, Muda, AO, Russo, A, Falcone, A & Tonini, G 2012, 'PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients', Journal of Cellular Physiology, vol. 227, no. 3, pp. 927-933. https://doi.org/10.1002/jcp.22801

Vincenzi, Bruno ; Santini, Daniele ; Perrone, Giuseppe ; Graziano, Francesco ; Loupakis, Fotios ; Schiavon, Gaia ; Frezza, Anna Maria ; Ruzzo, Anna Maria ; Rizzo, Sergio ; Crucitti, Pierfilippo ; Galluzzo, Sara ; Zoccoli, Alice ; Rabitti, Carla ; Muda, Andrea Onetti ; Russo, Antonio ; Falcone, Alfredo ; Tonini, Giuseppe. / PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients. In: Journal of Cellular Physiology. 2012 ; Vol. 227, No. 3. pp. 927-933.

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abstract = "PML regulates a wide range of pathways involved in tumorigenesis, such as apoptosis, which is also one of the main mechanisms through which oxaliplatin and fluoropyrimidine exert their antineoplastic activity. The present study aims to investigate PML expression as a predictive factor of oxaliplatin/fluoropyrimidine therapy efficacy. Seventy-four metastatic colorectal cancer patients who received oxaliplatin/floropyrimidine-based first line therapy have been included in this retrospective study. PML expression was assessed by immunohistochemistry. PML down-regulation was detected in 39 (52.7%) patients (14 complete and 25 partial PML loss). RR was significantly lower (25.6%) in patients with PML down-regulation than in patients with preserved PML expression (60%) (P=0.006). Median TTP was 5.5 months when PML was down-regulated versus 11.9 months in case of preserved PML expression (P",

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AU - Loupakis, Fotios

AU - Schiavon, Gaia

AU - Frezza, Anna Maria

AU - Ruzzo, Anna Maria

AU - Rizzo, Sergio

AU - Crucitti, Pierfilippo

AU - Galluzzo, Sara

AU - Zoccoli, Alice

AU - Rabitti, Carla

AU - Muda, Andrea Onetti

AU - Russo, Antonio

AU - Falcone, Alfredo

AU - Tonini, Giuseppe

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PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients

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