Pneumococcal colonization in older adults

Susanna Esposito, Daniela Mari, Luigi Bergamaschini, Annalisa Orenti, Leonardo Terranova, Luca Ruggiero, Valentina Ierardi, Monia Gambino, Francesco Della Croce, Nicola Principi

Research output: Contribution to journalArticle

Abstract

Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 %, ≥75 years), 41 (9.8 %) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 % confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 % CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 % CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 % CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 %) of the subjects who were

Original languageEnglish
Article number2
JournalImmunity and Ageing
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 12 2016

Fingerprint

Odds Ratio
Confidence Intervals
Carrier State
Pneumococcal Vaccines
Italy
Heart Diseases
Multivariate Analysis
Age Groups
Demography
Morbidity

Keywords

  • 13-valent pneumococcal conjugate vaccine
  • 13-valent pneumococcal vaccine
  • 23-valent polysaccharide pneumococcal vaccine
  • Invasive pneumococcal disease
  • Pneumococcal carriage
  • Pneumococcal colonization
  • Pneumococcal vaccination
  • Prevention
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Immunology
  • Ageing

Cite this

Esposito, S., Mari, D., Bergamaschini, L., Orenti, A., Terranova, L., Ruggiero, L., ... Principi, N. (2016). Pneumococcal colonization in older adults. Immunity and Ageing, 13(1), [2]. https://doi.org/10.1186/s12979-016-0057-0

Pneumococcal colonization in older adults. / Esposito, Susanna; Mari, Daniela; Bergamaschini, Luigi; Orenti, Annalisa; Terranova, Leonardo; Ruggiero, Luca; Ierardi, Valentina; Gambino, Monia; Croce, Francesco Della; Principi, Nicola.

In: Immunity and Ageing, Vol. 13, No. 1, 2, 12.01.2016.

Research output: Contribution to journalArticle

Esposito, S, Mari, D, Bergamaschini, L, Orenti, A, Terranova, L, Ruggiero, L, Ierardi, V, Gambino, M, Croce, FD & Principi, N 2016, 'Pneumococcal colonization in older adults', Immunity and Ageing, vol. 13, no. 1, 2. https://doi.org/10.1186/s12979-016-0057-0
Esposito S, Mari D, Bergamaschini L, Orenti A, Terranova L, Ruggiero L et al. Pneumococcal colonization in older adults. Immunity and Ageing. 2016 Jan 12;13(1). 2. https://doi.org/10.1186/s12979-016-0057-0
Esposito, Susanna ; Mari, Daniela ; Bergamaschini, Luigi ; Orenti, Annalisa ; Terranova, Leonardo ; Ruggiero, Luca ; Ierardi, Valentina ; Gambino, Monia ; Croce, Francesco Della ; Principi, Nicola. / Pneumococcal colonization in older adults. In: Immunity and Ageing. 2016 ; Vol. 13, No. 1.
@article{bd07477bc94047d8a0cb8dae778dbe23,
title = "Pneumococcal colonization in older adults",
abstract = "Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 {\%}, ≥75 years), 41 (9.8 {\%}) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 {\%} confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 {\%} CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 {\%} CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 {\%} CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 {\%}) of the subjects who were",
keywords = "13-valent pneumococcal conjugate vaccine, 13-valent pneumococcal vaccine, 23-valent polysaccharide pneumococcal vaccine, Invasive pneumococcal disease, Pneumococcal carriage, Pneumococcal colonization, Pneumococcal vaccination, Prevention, Streptococcus pneumoniae",
author = "Susanna Esposito and Daniela Mari and Luigi Bergamaschini and Annalisa Orenti and Leonardo Terranova and Luca Ruggiero and Valentina Ierardi and Monia Gambino and Croce, {Francesco Della} and Nicola Principi",
year = "2016",
month = "1",
day = "12",
doi = "10.1186/s12979-016-0057-0",
language = "English",
volume = "13",
journal = "Immunity and Ageing",
issn = "1742-4933",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Pneumococcal colonization in older adults

AU - Esposito, Susanna

AU - Mari, Daniela

AU - Bergamaschini, Luigi

AU - Orenti, Annalisa

AU - Terranova, Leonardo

AU - Ruggiero, Luca

AU - Ierardi, Valentina

AU - Gambino, Monia

AU - Croce, Francesco Della

AU - Principi, Nicola

PY - 2016/1/12

Y1 - 2016/1/12

N2 - Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 %, ≥75 years), 41 (9.8 %) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 % confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 % CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 % CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 % CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 %) of the subjects who were

AB - Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 %, ≥75 years), 41 (9.8 %) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 % confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 % CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 % CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 % CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 %) of the subjects who were

KW - 13-valent pneumococcal conjugate vaccine

KW - 13-valent pneumococcal vaccine

KW - 23-valent polysaccharide pneumococcal vaccine

KW - Invasive pneumococcal disease

KW - Pneumococcal carriage

KW - Pneumococcal colonization

KW - Pneumococcal vaccination

KW - Prevention

KW - Streptococcus pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=84953865899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84953865899&partnerID=8YFLogxK

U2 - 10.1186/s12979-016-0057-0

DO - 10.1186/s12979-016-0057-0

M3 - Article

AN - SCOPUS:84953865899

VL - 13

JO - Immunity and Ageing

JF - Immunity and Ageing

SN - 1742-4933

IS - 1

M1 - 2

ER -