Pneumococcal colonization in older adults

Susanna Esposito, Daniela Mari, Luigi Bergamaschini, Annalisa Orenti, Leonardo Terranova, Luca Ruggiero, Valentina Ierardi, Monia Gambino, Francesco Della Croce, Nicola Principi

Research output: Contribution to journalArticlepeer-review


Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 %, ≥75 years), 41 (9.8 %) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 % confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 % CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 % CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 % CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 %) of the subjects who were

Original languageEnglish
Article number2
JournalImmunity and Ageing
Issue number1
Publication statusPublished - Jan 12 2016


  • 13-valent pneumococcal conjugate vaccine
  • 13-valent pneumococcal vaccine
  • 23-valent polysaccharide pneumococcal vaccine
  • Invasive pneumococcal disease
  • Pneumococcal carriage
  • Pneumococcal colonization
  • Pneumococcal vaccination
  • Prevention
  • Streptococcus pneumoniae

ASJC Scopus subject areas

  • Immunology
  • Ageing


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