TY - JOUR
T1 - Pneumococcal colonization in older adults
AU - Esposito, Susanna
AU - Mari, Daniela
AU - Bergamaschini, Luigi
AU - Orenti, Annalisa
AU - Terranova, Leonardo
AU - Ruggiero, Luca
AU - Ierardi, Valentina
AU - Gambino, Monia
AU - Croce, Francesco Della
AU - Principi, Nicola
PY - 2016/1/12
Y1 - 2016/1/12
N2 - Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 %, ≥75 years), 41 (9.8 %) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 % confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 % CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 % CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 % CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 %) of the subjects who were
AB - Background: Little is known about pneumococcal carrier states in older adults. The main aim of this study was to evaluate pneumococcal colonization patterns among older adults in two centres in Milan, Italy, before the widespread use of the 13-valent pneumococcal vaccine (PCV13) in this age group, to investigate demographic and clinical features that are associated with pneumococcal colonization and to estimate the potential coverage offered by PCV13. Results: Among 417 adults ≥65 years old (171, 41.1 %, ≥75 years), 41 (9.8 %) were pneumococcal carriers. Univariate and multivariate analyses revealed that pneumococcal colonization was significantly less common among individuals with underlying co-morbidities than among those without (odds ratio [OR] 0.453, 95 % confidence interval [CI] 0.235-0.875, p = 0.018; adjusted OR 0.503, 95 % CI 0.255-0.992, p = 0.047). Moreover, among these patients, those with cardiac disease had a significantly lower risk of colonization (OR 0.308, 95 % CI 0.119-0.795, p = 0.015; adjusted OR 0.341, 95 % CI 0.13-0.894, p = 0.029). Only one vaccinated subject who received 23-valent polysaccharide pneumococcal vaccine (PPV23) was colonized. Twenty-five (89.3 %) of the subjects who were
KW - 13-valent pneumococcal conjugate vaccine
KW - 13-valent pneumococcal vaccine
KW - 23-valent polysaccharide pneumococcal vaccine
KW - Invasive pneumococcal disease
KW - Pneumococcal carriage
KW - Pneumococcal colonization
KW - Pneumococcal vaccination
KW - Prevention
KW - Streptococcus pneumoniae
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U2 - 10.1186/s12979-016-0057-0
DO - 10.1186/s12979-016-0057-0
M3 - Article
AN - SCOPUS:84953865899
VL - 13
JO - Immunity and Ageing
JF - Immunity and Ageing
SN - 1742-4933
IS - 1
M1 - 2
ER -