Pneumonectomy with and without induction chemo-radiotherapy for non-small cell lung cancer: Short and long-term results from a single centre

S. Margaritora, A. Cesario, G. Cusumano, V. Dall'armi, V. Porziella, E. Meacci, F. Lococo, R. D'angelillo, M. T. Congedo, P. Granone

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND OBJECTIVES: Pneumonectomy for non small cell lung cancer (NSCLC) after induction radio-chemotherapy (IT) has been associated with high peri-operative risk and its safety and efficacy is still debated. The aim of this retrospective study was to compare short and long-term results of pneumonectomy in patients treated with and without IT (radiotherapy plus chemotherapy) for NSCLC. MATERIALS AND METHODS: From 1995 to 2008, 85 consecutive patients underwent pneumonectomy: 49 received pre-operative radiotherapy and chemotherapy (IT group), and 36 patients did not (non-IT group). Peri-operative and long-term outcomes were compared. RESULTS: Major complications rate was 14.3% for IT group and 16.7% for non-IT group (p = n.s.). Mortality rate was 2% in IT group and 5.5% in non- IT group (p = n.s.). Post-operative hospital stay was significantly longer in the IT group (p <0.0001) as the need for blood transfusion (p = 0.002). Indeed, the mortality rate was similar in the left- and right-sided operations. 5 years survival was 45.3% for IT group and 38.4% for non-IT group (p = n.s.) and 5 year disease free survival rates were 42.3% vs. 37.8% for the two groups, respectively (p = n.s.). Among the clinical, surgical and pathological features no differences on long term outcomes were found with regards to IT. DISCUSSION: Pneumonectomy is a feasible and safe procedure even after pre-operative IT. Our results showed a prolonged hospitalization and the need for blood transfusion in the IT group.

Original languageEnglish
Pages (from-to)29-40
Number of pages12
JournalEuropean Review for Medical and Pharmacological Sciences
Volume17
Issue number1
Publication statusPublished - 2013

Keywords

  • Long term survival
  • Morbidity
  • Mortality
  • Non small cell lung cancer
  • Pneumonectomy
  • Radio-chemotherapy

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

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