PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease

Salvatore Petta, Luca Valenti, Giulio Marchesini, Vito Di Marco, Anna Licata, Calogero Cammà, Maria Rosa Barcellona, Daniela Cabibi, Benedetta Donati, Anna Fracanzani, Stefania Grimaudo, Gaspare Parrinello, Rosaria Maria Pipitone, Daniele Torres, Silvia Fargion, Giuseppe Licata, Antonio Craxì

Research output: Contribution to journalArticle

Abstract

Background and Aim:To evaluate if the presence of carotid atherosclerosis in patients with NAFLD, could be related to gene variants influencing hepatic fat accumulation and the severity of liver damage.Methods:We recorded anthropometric, metabolic and histological data(Kleiner score) of 162 consecutive, biopsy-proven Sicilian NAFLD patients. Intima-media thickness(IMT), IMT thickening(IMT≥1 mm) and carotid plaques(focal thickening of >1.3 mm at the level of common carotid artery) were evaluated using ultrasonography. IL28B rs12979860 C>T, PNPLA3 rs738409 C>G, GCKR rs780094 C>T, LYPLAL1 rs12137855 C>T, and NCAN rs2228603 C>T single nucleotide polymorphisms were also assessed. The results were validated in a cohort of 267 subjects with clinical or histological diagnosis of NAFLD from Northern Italy, 63 of whom had follow-up examinations.Results:Carotid plaques, IMT thickening and mean maximum IMT were similar in the two cohorts, whereas the prevalence of diabetes, obesity, NASH, and PNPLA3 GG polymorphism(21%vs.13%, p = 0.02) were significantly higher in the Sicilian cohort. In this cohort, the prevalence of carotid plaques and IMT thickening was higher in PNPLA3 GG compared to CC/CG genotype(53%vs.32%, p = 0.02; 62%vs.28%, p

Original languageEnglish
Article numbere74089
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 16 2013

    Fingerprint

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Petta, S., Valenti, L., Marchesini, G., Di Marco, V., Licata, A., Cammà, C., Barcellona, M. R., Cabibi, D., Donati, B., Fracanzani, A., Grimaudo, S., Parrinello, G., Pipitone, R. M., Torres, D., Fargion, S., Licata, G., & Craxì, A. (2013). PNPLA3 GG Genotype and Carotid Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease. PLoS One, 8(9), [e74089]. https://doi.org/10.1371/journal.pone.0074089