PNPLA3 I148M Polymorphism, Clinical Presentation, and Survival in Patients with Hepatocellular Carcinoma

Luca Valenti, Benedetta Maria Motta, Giorgio Soardo, Massimo Iavarone, Benedetta Donati, Angelo Sangiovanni, Alessia Carnelutti, Paola Dongiovanni, Raffaela Rametta, Cristina Bertelli, Floriana Facchetti, Massimo Colombo, Silvia Fargion, Anna Ludovica Fracanzani

Research output: Contribution to journalArticlepeer-review

Abstract

Background & Aims:Aim of this study was to evaluate whether the PNPLA3 I148M polymorphism, previously associated with hepatocellular carcinoma (HCC) risk, influences the clinical presentation of HCC and survival.Methods:we considered 460 consecutive HCC patients referred to tertiary care centers in Northern Italy, 353 with follow-up data.Results:Homozygosity for PNPLA3 148M at risk allele was enriched in HCC patients with alcoholic liver disease or nonalcoholic fatty liver disease (ALD&NAFLD: relative risk 5.9, 95% c.i. 3.5-9.9; other liver diseases: relative risk 1.9, 95% c.i. 1.1-3.4). In ALD&NAFLD patients, the PNPLA3 148M allele was associated with younger age, shorter history of cirrhosis, less advanced (Child A) cirrhosis at HCC diagnosis, and lower HCC differentiation grade (p

Original languageEnglish
Article numbere75982
JournalPLoS One
Volume8
Issue number10
DOIs
Publication statusPublished - Oct 14 2013

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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