TY - JOUR
T1 - Podoplanin and E-cadherin expression in preoperative incisional biopsies of oral squamous cell carcinoma is related to lymph node metastases
AU - Foschini, Maria P.
AU - Leonardi, Elisa
AU - Eusebi, Leonardo Henry
AU - Farnedi, Anna
AU - Poli, Tito
AU - Tarsitano, Achille
AU - Cocchi, Roberto
AU - Marchetti, Claudio
AU - Gentile, Luciano
AU - Sesenna, Enrico
AU - Marucci, Gianluca
AU - Montebugnoli, Lucio
PY - 2013
Y1 - 2013
N2 - Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in planning the proper therapeutic procedures before surgery. To this end, immunohistochemical expressions of both E-cadherin and podoplanin were evaluated on preoperative incisional biopsies of OSCC from 102 patients. The probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found. Therefore, because of the strong association with LN metastases, high E-cadherin/low podoplanin immunohistochemical expression should also be assessed on preoperative incisional biopsies as a useful tool for evaluating the probability of early or late LN metastases of OSCCs.
AB - Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in planning the proper therapeutic procedures before surgery. To this end, immunohistochemical expressions of both E-cadherin and podoplanin were evaluated on preoperative incisional biopsies of OSCC from 102 patients. The probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found. Therefore, because of the strong association with LN metastases, high E-cadherin/low podoplanin immunohistochemical expression should also be assessed on preoperative incisional biopsies as a useful tool for evaluating the probability of early or late LN metastases of OSCCs.
KW - E-cadherin
KW - lymph node metastasis
KW - oral squamous carcinoma
KW - podoplanin
KW - preoperative biopsy
KW - prognosis
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U2 - 10.1177/1066896912471851
DO - 10.1177/1066896912471851
M3 - Article
C2 - 23349470
AN - SCOPUS:84875699173
VL - 21
SP - 133
EP - 141
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
SN - 1066-8969
IS - 2
ER -