Podoplanin and E-cadherin expression in preoperative incisional biopsies of oral squamous cell carcinoma is related to lymph node metastases

Maria P. Foschini, Elisa Leonardi, Leonardo Henry Eusebi, Anna Farnedi, Tito Poli, Achille Tarsitano, Roberto Cocchi, Claudio Marchetti, Luciano Gentile, Enrico Sesenna, Gianluca Marucci, Lucio Montebugnoli

Research output: Contribution to journalArticlepeer-review

Abstract

Metastases to cervical lymph nodes (LNs) are an important independent adverse indicator in the prognosis of oral squamous cell carcinoma (OSCC). An accurate evaluation of molecular patterns favoring the metastatic process can be helpful in predicting cases of OSCC with elevated probability of early or late metastases and, moreover, in planning the proper therapeutic procedures before surgery. To this end, immunohistochemical expressions of both E-cadherin and podoplanin were evaluated on preoperative incisional biopsies of OSCC from 102 patients. The probability to have or develop metastases was very low when high E-cadherin expression was found in a preoperative sample or when a low podoplanin expression was found. Therefore, because of the strong association with LN metastases, high E-cadherin/low podoplanin immunohistochemical expression should also be assessed on preoperative incisional biopsies as a useful tool for evaluating the probability of early or late LN metastases of OSCCs.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalInternational Journal of Surgical Pathology
Volume21
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • E-cadherin
  • lymph node metastasis
  • oral squamous carcinoma
  • podoplanin
  • preoperative biopsy
  • prognosis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery
  • Medicine(all)

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