Abstract
The vascular basement membrane (BM) is a thin and dense crosslinked extracellular matrix layer that covers and protects blood vessels. Understanding how cells cross the physical barrier of the vascular BM will provide greater insight into the potentially critical role of vascular BM breaching in cancer extravasation, leukocyte trafficking and angiogenic sprouting. In the last year, new evidence has mechanistically linked the breaching of vascular BM with the formation of specific cellular microdomains known as podosomes and invadopodia. These structures are specialized cell-matrix contacts with an inherent ability to degrade the extracellular matrix. Specifically, the formation of podosomes or invadopodia was shown as an important step in vascular sprouting and tumor cell extravasation, respectively. Here, we review and comment on these recent findings and explore the functions of podosomes and invadopodia within the context of pathological processes such as tumor dissemination and tumor angiogenesis.
| Original language | English |
|---|---|
| Pages (from-to) | 1370-1374 |
| Number of pages | 5 |
| Journal | Cell Cycle |
| Volume | 14 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2015 |
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Keywords
- Endothelial cell
- Invadopodia
- Podosome
- Rosette
- Tumor angiogenesis
- Tumor dissemination
- Vascular basement membrane
- Vascular sprouting
ASJC Scopus subject areas
- Medicine(all)
- Molecular Biology
- Developmental Biology
- Cell Biology
Cite this
Podosomes and invadopodia : Tools to breach vascular basement membrane. / Seano, Giorgio; Primo, Luca.
In: Cell Cycle, Vol. 14, No. 9, 2015, p. 1370-1374.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Podosomes and invadopodia
T2 - Tools to breach vascular basement membrane
AU - Seano, Giorgio
AU - Primo, Luca
PY - 2015
Y1 - 2015
N2 - The vascular basement membrane (BM) is a thin and dense crosslinked extracellular matrix layer that covers and protects blood vessels. Understanding how cells cross the physical barrier of the vascular BM will provide greater insight into the potentially critical role of vascular BM breaching in cancer extravasation, leukocyte trafficking and angiogenic sprouting. In the last year, new evidence has mechanistically linked the breaching of vascular BM with the formation of specific cellular microdomains known as podosomes and invadopodia. These structures are specialized cell-matrix contacts with an inherent ability to degrade the extracellular matrix. Specifically, the formation of podosomes or invadopodia was shown as an important step in vascular sprouting and tumor cell extravasation, respectively. Here, we review and comment on these recent findings and explore the functions of podosomes and invadopodia within the context of pathological processes such as tumor dissemination and tumor angiogenesis.
AB - The vascular basement membrane (BM) is a thin and dense crosslinked extracellular matrix layer that covers and protects blood vessels. Understanding how cells cross the physical barrier of the vascular BM will provide greater insight into the potentially critical role of vascular BM breaching in cancer extravasation, leukocyte trafficking and angiogenic sprouting. In the last year, new evidence has mechanistically linked the breaching of vascular BM with the formation of specific cellular microdomains known as podosomes and invadopodia. These structures are specialized cell-matrix contacts with an inherent ability to degrade the extracellular matrix. Specifically, the formation of podosomes or invadopodia was shown as an important step in vascular sprouting and tumor cell extravasation, respectively. Here, we review and comment on these recent findings and explore the functions of podosomes and invadopodia within the context of pathological processes such as tumor dissemination and tumor angiogenesis.
KW - Endothelial cell
KW - Invadopodia
KW - Podosome
KW - Rosette
KW - Tumor angiogenesis
KW - Tumor dissemination
KW - Vascular basement membrane
KW - Vascular sprouting
UR - http://www.scopus.com/inward/record.url?scp=84983535252&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983535252&partnerID=8YFLogxK
U2 - 10.1080/15384101.2015.1026523
DO - 10.1080/15384101.2015.1026523
M3 - Article
AN - SCOPUS:84983535252
VL - 14
SP - 1370
EP - 1374
JO - Cell Cycle
JF - Cell Cycle
SN - 1538-4101
IS - 9
ER -