Point mutations of the BCL-6 gene in Burkitt's lymphoma

Daniela Capello, Antonino Carbone, Cristina Pastore, Annunziata Gloghini, Giuseppe Saglio, Gianluca Gaidano

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

BCL-6 codes for a transcription factor implicated in chromosomal translocations of diffuse large cell lymphomas. Recent evidence indicates that BCL-6 may also be altered by mutations of its 5' non-coding regions. In this study we have investigated the distribution of BCL-6 5' mutations among 35 Burkitt's lymphoma cases representative of the epidemiologic variants of the disease. Mutations were detected in 6/21 (28.6%) sporadic Burkitt's lymphomas and 7/14 (50%) endemic Burkitt's lymphomas. These data expand the spectrum of B-cell non-Hodgkin's lymphomas associated with BCL-6 5' mutations and have implications for the pathogenesis, histogenesis and clinical monitoring of Burkitt's lymphoma.

Original languageEnglish
Pages (from-to)168-170
Number of pages3
JournalBritish Journal of Haematology
Volume99
Issue number1
Publication statusPublished - 1997

Fingerprint

Burkitt Lymphoma
Point Mutation
Mutation
Genes
Genetic Translocation
Lymphoma, Large B-Cell, Diffuse
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Transcription Factors

Keywords

  • AIDS
  • BCL-6
  • Burkitt's lymphoma
  • Genetic lesion
  • Germinal centre

ASJC Scopus subject areas

  • Hematology

Cite this

Capello, D., Carbone, A., Pastore, C., Gloghini, A., Saglio, G., & Gaidano, G. (1997). Point mutations of the BCL-6 gene in Burkitt's lymphoma. British Journal of Haematology, 99(1), 168-170.

Point mutations of the BCL-6 gene in Burkitt's lymphoma. / Capello, Daniela; Carbone, Antonino; Pastore, Cristina; Gloghini, Annunziata; Saglio, Giuseppe; Gaidano, Gianluca.

In: British Journal of Haematology, Vol. 99, No. 1, 1997, p. 168-170.

Research output: Contribution to journalArticle

Capello, D, Carbone, A, Pastore, C, Gloghini, A, Saglio, G & Gaidano, G 1997, 'Point mutations of the BCL-6 gene in Burkitt's lymphoma', British Journal of Haematology, vol. 99, no. 1, pp. 168-170.
Capello D, Carbone A, Pastore C, Gloghini A, Saglio G, Gaidano G. Point mutations of the BCL-6 gene in Burkitt's lymphoma. British Journal of Haematology. 1997;99(1):168-170.
Capello, Daniela ; Carbone, Antonino ; Pastore, Cristina ; Gloghini, Annunziata ; Saglio, Giuseppe ; Gaidano, Gianluca. / Point mutations of the BCL-6 gene in Burkitt's lymphoma. In: British Journal of Haematology. 1997 ; Vol. 99, No. 1. pp. 168-170.
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